Medical description: Generic Acillin is a semisynthetic antibiotic substance utilized for the medical cure of various contagious diseases of the urinoexcretory ways, breathing passages and digestive tract. It is white crystalline powder that owns a bitter taste, is sustainable in an acidic environment. It is slightly solvable in water and is practically indissoluble in alcohol. The drug is gained by acylation of 6-aminopenicillanic acid residue aminophenylalanine acid. It raises the effect of oral anticoagulants and is contraindicated in case of hypersensitivity to penicillin.
Synonyms: Ampicilin, Apmax
Consult your helth
care professional before using any drug.
What is Acillin?
Generic Acillin is used in the postoperative soft tissue infections, pyoderma, infections of the digestive system evoked by microorganisms sensitive to it (cholecystitis, intestinal infections enterocolitis which are provoked by Salmonella, enteric and dysentery bacillus), tonsillitis, laryngitis, pleurisy, peritonitis, sepsis, etc. In connection with the allocation of this drug with urine in an unmodified form and in high concentrations, the medicament is very effective for urogenital infections (pyelitis, cystitis and gonorrhoea) caused by Escherichia coli, Proteus, enterococci or mixed infection. Acillin is prescribed for infectious diseases of the respiratory tract (pneumonia, bronchopneumonia, lung abscess, bronchitis, chronic bronchitis caused by Pfeiffer’s bacillus) which is difficult to treat with other kinds of antibiotics.
The mode of administration and dosages
Acillin is taken orally for 0.5–1 hour before meals or 2 hours after meals. It is assigned orally at a dose of 0.4–0.5 g every 6 hours in the medical therapy of ailments which are provoked by gram-positive pathogens and Haemophylus influenzae. In the treatment of diseases caused by gram-negative pathogens and enterococci, the medication is accepted in a daily dose from 3 to 6 grams, divided into 4-6 doses.
A single dose of the substance for adults is 0.25–0.5 g every 4-6 hours. The average daily dose is 3 grams in severe infections administered in daily doses of 6 g or more. Children can take Acillin only if it was prescribed by the doctor (for children who aren’t 13years old, the drug is appointed from 100 to 200 mg per 1 kg of body weight per day, but not more than the daily dose for grown-ups). The length of treatment depends on the seriousness of the disease and ranges from 5-10 days to 2-3 weeks.
Side effects and counterindications
The medicament is usually well tolerated, but may occur occasionally dyspeptic symptoms (belching, nausea, vomiting). A patient can notice possible effects of dysbiosis associated with the effect of the medicine on the intestinal flora (increased flatus, diarrhea, candidiasis) and allergic reactions (nettle-rash, spotty-nodular rash) in individuals with high individual sensitivity to penicillin. When you buy Generic Acillin, make sure that you don’t have hypersensitivity to penicillin, severe renal failure, allergic diseases (hay fever, asthma). This medication is prescribed with great care to examinees with impaired liver function. The usage of Acillin is possible during pregnancy, but consuming the drug during lactation may cite to changes in intestinal micro flora and cause allergic reactions in a baby.
It is absolutely contra-indicated to drink alcohol during the treatment with Generic Acillin. Debilitated patients who have the long-term treatment with this medical preparation may get the development of superinfection. Therefore it is recommended for them to accept a vitamin B complex, vitamin C, and anti-fungal drugs such as Nystatin and Levorin. Acillin enhances the effect of anticoagulants which are taken orally.
Sodium salt of Acillin is semisynthetic broad— spectrum penicillin. The antibiotic is rapidly absorbed into the blood and has low toxicity. Acillin trihydrate is an antimicrobial agent. The indications for its usage are the same as that for the sodium salt of Acillin. Acillin trihydrate is highly effective in urinary tract infections, as it is excreted in the urine in unchanged form and in high concentrations. Ampioks is a combination drug containing Acillin and Oxacillin. Ampioks has antimicrobial properties, combining spectrum of antimicrobial action of Acillin and Oxacillin.
Composition, product form, the effect spectrum and pharmacokinetics of the drug
If you decide to order Generic Acillin, take into consideration that it is on the market in 2 forms:
1) Tablets containing 0.25 g of Acillin, 10 tablets in a package
2) Capsules of 0.25 g (pack of 10, 16 or 25 capsules) and 0.5 g (16 capsules per pack)
The drug has a bactericidal effect on the same group of gram-positive bacteria, and Penicillin, Tetracycline and Chloramphenicol (and, in addition, the number of gram-negative bacteria, meningococcal disease, Neisseria gonorrhoea, Salmonella, Escherichia coli, Haemophilus influenzae of Peiffer, Shigella, Yersinia, mirabelle Proteus), but exceeds them in activity against sensitive pyogenic cocci, the action closer to the broad-spectrum antibiotics.
Most of the strains of enterococci, pneumococci and hemolytic streptococci are sensitive to the antibiotic’s action. The medicament has no effect on penicillin resistant staphylococci, since destroyed by penicillinase. The preparation has no effect on Pseudomonas bacillus and Proteus (except Proteus mirabilis).
Acillin is sustainable in an acidic environment, not collapsing and not inactivating in the stomach, is well absorbed while taken orally, reaching a maximum concentration in the blood after 2 hours. The drug is excreted in urine, the concentration in urine of 5000-6000 mg/ml. In pleural and synovial fluids the content of this medical preparation is equal to 65-80% of the drug concentration in blood serum.
Acillin is an antibiotic applied for the cure of communicable ailments of liver, the respiratory, gastrointestinal and urinary tracts.
A broad-spectrum antibiotic – Accillin.
Generic Acillin is a use-proven preparation in a series of semisynthetic penicillins, whose effectiveness allows you to use it actively nowadays. It is a broad-spectrum antibiotic with a bactericidal effect, meaning that it inhibits the growth and development of bacteria, as bacteriostatic drugs, and completely destroys them. The mechanism of action of this medicine is as follows: it inhibits the transpeptidase (enzyme involved in protein synthesis), prevents the formation of peptide bonds and intervenes in the final stage of peptidoglycan synthesis cell membrane dividing bacteria, causing its death. The list of objects of rapeat attention of Acillin is pretty voluminous. The drug shows activity against wide range of gram-positive and gram-negative bacteria.
How to be treated with this medication?
The method of production of Generic Acillin involves both oral and parenteral accepting. In the first case, there are tablets and capsules, in the second one — it is powder for preparation of the solution for intravenous and intramuscular introduction. The injectable form of the medicine is mainly used for hard occurring infections or in infections of moderate severity. So, during meningitis the medicament is input daily for 14 g for 6-8 intramuscular injection, during gonococcal urethritis the drug is used double 0.5 grams in the course of one day.
The solution is prepared on pharmaceutical water for injection (solution for intravenous administration is allowed to prepare on the saline). The duration of treatment depends upon the severity and nature of the disease and can vary from 5 days to several months. The standard dosage of Acillin for internal usage is 0.25 g 4 times every day, which is taken half an hour before meals. The maximum daily dose is 3 g. During a course (not a single) accepting, it is recommended to control the condition of the liver, kidneys and blood-forming organs. If a person has chronic infections, it is necessary to replace periodically an antibacterial substance to avoid the development of superinfection due to the growth insensitive to Acillin’s microorganisms.
Professional’s opinion and ordinary consumers’ reviews.
Christopher Roberts, a practicing surgeon
The medicine is very popular owing to its safe application, but usually according to the results of a bacteriological inoculation, as well as in the capacity of a starting therapy there can be a risk of falling into an insensitive strain. Side effects are rare, usually in the form of allergic skin manifestations that are easily stopped with the abolition of Generic Acillin and the appointment of antihistamines. The preparation is a powerful antibiotic that has been utilized in medicine for a long period of time, but, however, it could get a very extensive list of microorganisms that are insensitive to it. If you are going to buy Generic Acillin, you should remember that today it is convenient for the usage rather in the hospital than in the ambulance situation.
Margaret, a consumer
It is vital to have a bacteriological inoculation done and then to have the medication prescribed. This drug was helpful for me in spite of the fact that at the beginning I had skin rash. However, after taking of antihistamines redness has gone. If you want to be treated with the help of this drug, you should consult you medical specialist, as it can be a real salvation for someone, and can do a lot of harm for others.