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Generic Amoxicilin

Medical description: Generic Amoxicilin is an antibacterial acid-resistant substance of a broad range of semisynthetic penicillins. It hinders transpeptidase, disrupts the synthesis of the peptidoglycan (the component of the bacterial cell wall) in the interval of separation and growth, lysis of bacteria. This medicament is proactive against aerobic gram-positive bacteria and aerobic gram-negative bacteria. Microorganisms, making penicillinase, are sustainable to the action of this antibiotic. Its effect develops within 15-30 minutes after the drug’s accepting and endures 8 hours.

Generic Amoxicilin
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Consult your helth care professional before using any drug.

Medication guide:

Amoxicillin is a wide-spectrum drug

People buy Generic Amoxicilin when it is appointed by a doctor in case of bacterial contagions provoked by receptive microorganisms: contagions of the respiratory tract and ENT-organs (tonsillitis,  sinusitis, pharyngitis, pneumonia, acute otitis; bronchitis); infections of the urogenital system (urethritis, endometritis, cystitis, pyelonephritis, pyelitis, gonorrhea, cervicitis); gastrointestinal infections (typhoid fever, peritonitis, enterocolitis, cholecystitis, cholangitis); contagions of skin and mild tissues (impetigo, erysipelas, secondarily infected dermatoses), Lyme disease (borreliosis), leptospirosis, listeriosis, dysentery, salmonellosis, meningitis, sepsis, endocarditis (prophylaxis).

It is taken inside before or after meals. Grown-ups and children over 10 years (weighing more than 40 kg) are appointed to take 500 mg 3 times daily; in severe infections - by 0.75-1 g 3 times a day. Children are prescribed to take this medication in the form of suspension: from 5 to 10 years - 250 mg (5 ml of suspension) 3 times daily; 2-5 years - 125 mg (2.5 ml) 3 times a day; under 2 years - 20 mg/kg of body weight per day, divided into 3 doses. In premature infants and neonates, the interval between doses are reduced and/or increased. The course of a medical therapy is 5-12 days.

The preparation of slurry: add water in the bottle to the mark and shake well. The resulting slurry is steady at room temperature for 14 days. Before every usage, the suspension should be shaken. 5 ml prepared suspension (1 scoop) contain 250 mg of Generic Amoxicilin. The antibiotic is prescribed in the dose of 3 g once in acute uncomplicated gonorrhea; during the medical therapy of females it is advised to recur the accepting of the specified dose.  Adults take 1.5-2 g 3 or 1-1.5 g 4 times a day in acute infectious gastrointestinal diseases (paratyphoid, typhoid) and biliary tract, gynecological infectious diseases.

Grown-ups take 0.5-0.75 g 4 times a day for 6-12 days in leptospirosis. Adults accept 1.5 to 2 g 3 times a day for 2-4 weeks in salmonellosis. For prevention of endocarditis during small surgical intervention adults should take from 3 to 4 g for 1 h prior to the procedure. If it is necessary, the second dose is appointed after 8-9 hours. The dosage for children should be cut down in 2 times.

Pharmacokinetics and special indications

Food doesn’t influence absorption; the antibiotic isn’t annihilated in the stomach’s acidic environment. In high concentrations it is  retrieved in plasma, sputum, bronchial secretions (in purulent bronchial secret weak distribution), pleural and peritoneal fluid, urine, contents of skin blisters, lung tissue, intestinal mucosa, female genital organs, prostate gland, middle ear fluid, bone, adipose tissue, the gallbladder (normal liver), fetal tissues. If the dosage is increased in 2 times, the concentration is also heightened in 2 times. It is displayed on 50-70% of the kidneys in an unmodified form through canalicular secretion (80%) and glomerular filtration (20%), liver - 10-20%.

It is deduced in breast milk in a small amount. Amoxicillin is taken out by hemodialysis. There is a necessity to carry out monitoring functions of blood, liver and kidneys during the treatment course. It is permissible to get the growth of superinfection due to the increase of insensitive to microflora, which demands a respective change in antibiotic therapy. When the antibiotic is appointed to patients with bacteremia, it may develop reactions of bacteriolysis. It is possible cross-allergic responses to cephalosporin antibiotics in examinees with hypersensivity to penicillins.

You should avoid antidiarrhoeal drugs that lessen bowel movements in the medical cure of mild diarrhea on basis of a course treatment. Patients can kaolin or attapulgite antidiarrheal remedies. If you have severe diarrhea, you should consult a doctor. The treatment definitely lasts 48-72 hours after the extinction of clinical signs of disease. During the simultaneous usage of estrogen oral contraceptives and Generic Amoxicilin, it is possible to use other additional methods of contraception. Never use Amoxicillin with alcohol. The combined accepting may lead to severe liver and kidney disorders.

Drug interaction

When you order Generic Amoxicilin, remember that it is pharmaceutically inconsistent with aminoglycosides (it cannot be mixed in order to avoid mutual inaction). Antacids, glucosamine, laxatives, food, aminoglycosides retard and cut down absorption; ascorbic acid heightens the absorption. Bactericidal antibiotics (comprising cephalosporins, aminoglycosides, cycloserine, rifampicin and vancomycin) have a synergistic effect; bacteriostatic drugs (sulfonamides, lincosamides, macrolides, chloramphenicol, tetracyclines) have an antagonistic effect.

The antibiotic increases the efficiency of consequential anticoagulants (hindering intestinal microflora, shortens the synthesis of vitamin K and prothrombin index); reduces the productivity of estrogen oral contraceptives and medicines, in the process of metabolism which is formed paraaminobenzoic acid, ethinyl estradiol is the risk of breakthrough bleeding. Allopurinol, diuretics, phenylbutazone and oxyphenbutazone are drugs that block tubular secretion, reduce tubular secretion, increase concentration. Allopurinol raises the danger of skin rash. It also decreases the purification and enhances the methotrexate toxicity. Amoxicilin improves the digoxin’s absorption.

Amoxicilin is an antibiotic of a class of semisynthetic penicillins with a wide range of action. It possesses a bactericidal effect.


 

Generic Amoxicilin

The antibiotic for curing contagious diseases.

Generic Amoxicilin is an antibacterial combination drug. The active substances are: Amoxicilin is an antibiotic of the penicillin class of a broad-range and decelerator of beta-lactometers - clavulanic acid that hinders the annihilation of Amoxicilin due to the formation of sustainable complexes with beta-lactamases: the resulting complexes are inactive and resistant.

Amoxicilin is productive against bacteria having sensitivity to it. By including in the preparation of the beta-lactamase inhibitor, the drug can be prescribed for infections which are resistant to this antibiotic.  The usage of Generic Amoxicilin with food doesn’t affect absorption of the medicament. The decay-period of clavulanic acid is 60-70 minutes, for Amoxicillin is 78 minutes. These both substances permeate into the tissue and liquid medium the organisms easily; especially they accrue in the secret of the maxillary sinuses, middle ear cavity, lungs, ovaries, pleural and peritoneal fluids and uterus.

The constituents of the medicine penetrate the blood-brain barrier in meningitis. They permeate also through the barrier of placenta and are identified in trace amounts in breast milk.   During the bolus injection of the antibiotic in a dosage of 1.2 g of observed maximum plasma concentration of clavulanic acid 28.5 mg/l, Amoxicilin - 105,4 mg/ml. The maximum concentration of these substances in liquid media of the organism is determined after 60 minutes. The substances are connected with plasma proteins, respectively, by 22-30% and 17-20%.

Possible side effects and other additional information.

People, who buy Generic Amoxicilin, should pay attention to side effects that are usually temporary in nature and have easy severity. Digestive system: diarrhea (4.1%), nausea (3%), vomiting (1,8%) and dyspepsia (1.6 %); rarely flatulence, gastritis, anorexia, glossitis, stomatitis, enterocolitis or discoloration of the tongue. During or after discontinuation of therapy this antibiotic may produce pseudomembranous evoked by toxins.

Skin integument: rash, urticaria, angioedema, rarely — toxic epidermal necrolysis, multiform erythema, exfoliative dermatitis, syndrome Stevens — Johnson. Nervous system: rare — agitation, headache, anxiety, insomnia, dizziness, inappropriate behavior, convulsions, hyperactivity and confusion.   Blood system: anemia (involving hemolytic anemia, thrombocytopenia , leucopenia, agranulocytosis, eosinophilia.

Users’ opinions.

Emily: I caught a cold and was prescribed to take this medicine. I decided to buy Generic Amoxicilin immediately when I left my doctor. I could feel its effectiveness several hours after its accepting. I didn’t have any side effects, so I am ready to take it in future, too.

Gregory: Amoxicillin is a strong and effective antibiotic. I used it when I had acute bronchitis and I got well in 4 or 5 days. In addition, to avoid dysbacteriosis, it is recommended to accept probiotics, but you shouldn’t choose any probiotics you like. Antibiotics and probiotics must be prescribed by a physician.

Laura: Some months ago my baby had a severe cold. Our pediatrician appointed to take Amoxicilin, besides it was prescribed to accept an antihistamine preparation and the drug supporting microflora.We followed the doctor’s instructions and were healthy in 5 days. As far as I know you also can order Generic Amoxicilin online.

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