Full Information about Antibiotic Generic Augmentin
Medical description: It is quite difficult to find a doctor who has never prescribed Augmentin for their patients. Therapists, pediatricians, urologists, gynecologists, ENT doctors - doctors of all specializations do not imagine their medical practice without the help of this effective antibiotic. In a lot of protocols for the treatment of various diseases Augmentin comes as the drug of choice, which means, that it is recommended by the Ministry of Health. And if you are looking for an effective method of getting rid of the common cold, tonsillitis or bronchitis, take a look at this piece of information.
Consult your helth
care professional before using any drug.
What is Augmentin?
The given medication is an effective drug which is taken for fighting different infections including common cold, bronchitis, tonsillitis and other conditions. It is very popular both in medical practice and for receiving it without a doctor’s prescription. You can buy Generic Augmentin on your own at any drugstore of the US, Australia and countries of Europe or order Generic Augmentin via Internet at one of the reliable online pharmacies.
The pharmacological properties.
The modern drug Augmentin consists of the combination of amoxicillin and clavulanic acid. The first one is a semi-synthetic antibiotic containing penicillin with a broad spectrum of antibacterial activity against a lot of gram-positive and negative microorganisms. It is sensitive to beta-lactamase action and decomposes under its influence, so the spectrum of activity of amoxicillin does not consist of the microorganisms that synthesize the enzyme.
The second one is a beta-lactam structure that is similar to penicillin, but it also has the ability to inactivate beta-lactamase enzymes that are produced by those microorganisms which are resistant to the action of cephalosporins and penicillins. The mechanism of action of the given drug is rather simple. The given antibiotic blocks the synthesis of the cell wall of the microorganisms that are quite sensitive to it and has therefore a bactericidal effect. Pharmacological effects of Generic Augmentin have only one active ingredient of the drug - amoxicillin. And clavulanic acid has no antibacterial action.
Dosage and administration.
Generic Augmentin is taken orally. The dosage regimen is established individually, depending on the age, body weight, renal function of the patient, and the severity of the infection. And in order to reduce the potentially possible violations of the gastrointestinal tract of the patients and in order to optimize the absorption, the medication should be received at the beginning of every meal. Minimum duration of the course of antibiotic therapy is 5 days.
The treatment should not be longer than 14 days without a consultation of the professional. If it is necessary, there may be conducted sequential therapy (first parenteral administration of the medication with a subsequent transition to oral). Keep in mind that 2 tablets of 250 mg drug + 125 mg are not equivalent to one tablet of Augmentin 500 mg plus 125 mg. Adult people and children of 12 years old and older weighing 40 kg or more should take 1 tablet of 500 mg + 125 mg of the medication three times a day.
Suspension of Augmentin - where to keep and how to make?
Suspensions and emulsions are biphasic systems. Look closely to the prepared suspension of Augmentin: powder does not dissolve, but just distributes in the water. You should not worry - it's not your inability to make the drugs. Just Amoxicillin, like most other antibiotics, is insoluble in water. Before the usage, you need to shake a bottle of medicine vigorously. Keep prepared suspension in a refrigerator.
There must be emphasized the word "prepared". If you bought the drug in advance, then there are enough ordinary shelves in a closed cabinet so that the powder retains its properties. If at the end of treatment some amount of medication left unused, do not leave it "just in case." Augmentin suspension can be stored for about three weeks after which the antibiotic is destroyed.
Interactions with other drugs.
By patients receiving Augmentin, there was a marked prolongation of bleeding time. The drug should be used with caution by patients receiving anticoagulants. It improves the action of anticoagulants since suppressing the intestinal flora and reduceing the synthesis of vitamin K and prothrombin. Concomitant use with allopurinol may cause allergic skin reactions. Diuretics, allopurinol, phenylbutazone, NSAIDs and other drugs that block tubular secretion, increase the concentration of amoxicillin. Antacids, glucosamine, laxatives and aminoglycosides slow down and reduce the absorption of Augmentin, but ascorbic acid increases it. Bactericidal antibiotics have a synergistic effect, bacteriostatic agents – the antagonistic one.
Cautions and precautions for usage.
Before you start having treatment with the help of Augmentin, the doctor needs to collect detailed medical history concerning previous hypersensitivity reactions of the patient to penicillins, cephalosporins or other substances that might cause an allergic reaction of the patient. There should be described serious and occasionally fatal hypersensitivity reactions (anaphylaxis) to penicillins.
The risk of these reactions is bigger by patients who have a history of hypersensitivity reactions to penicillins. In case of an allergic reaction you must stop treatment with Augmentin and start the appropriate alternative therapy. By severe anaphylactic reactions the patient should be immediately administered epinephrine. There may also be needed oxygen therapy, intravenous corticosteroids, and airway management, including intubation.
Augmentin is a popular and effective drug which is prescribed for patients that suffer from the common cold, bronchitis and other similar conditions.
Augmentin – a modern antibiotic for treatment of infections.
Both patients and doctors perceive Augmentin as a modern anti-bacterial agent. Meanwhile, the drug has been on the market for decades. The combination of amoxicillin and clavulanic acid, which became the basis of the drug, was developed in 1977-1978 by scientists of the British company Beecham. Later, in 1984, the pharmaceutical giant received a patent for the original Augmentin. Today, the drug continues to be produced by the GlaxoSmithKline Company. WHO - World Health Organization - included the given medication to the list of essential drugs.
The popularity of the drug around the world is so high, that it is among the ten best-selling antibiotics. Reviews of both patients and doctors about Generic Augmentin are virtually unanimous and only confirm the universal love to the given drug. It is sold in the drugstores of the US, Canada, Australia and European countries, so you can buy Generic Augmentin at the nearest drugstore even without a prescription of a doctor. There is also a good opportunity to order Generic Augmentin via Internet at one of the most reliable online pharmacies, which is even more convenient.
Structure and composition of the drug.
The structure of the drug includes two main ingredients: amoxicillin and clavulanic acid. Amoxicillin is a semi synthetic antibiotic containing penicillin that has a wide spectrum of action. It represents almost an analogue of Ampicillin and differs only in small structural changes in the chemical formula of the drug.
The structure of Augmentin includes Amoxicillin as a trihydrate. Clavulanic acid is a product of the fermentation of Gram-positive bacteria Streptomyces clavuligerus. This substance is a part of Augmentin in a form of the potassium salt. The medication is rich in forms of release. GlaxoSmithKline Company produces a multitude of different dosages of the drug. Writing about the dosage, the manufacturer specifies separate dosage of antibiotic (first number) and dosage of the clavulanate (second number). Each tablet is covered with film coating which protects the active substance from the aggressive action of hydrochloric acid environment of the human stomach.
Sometimes doctors, when prescribing Generic Augmentin, indicate the total dosage of the antibiotic and clavulanic acid. For example, you can often find a recipe of similar content: «Tab.Augmentini 1000mg». Obviously, the doctor meant antibiotic release form comprising 875 mg of amoxicillin and 125 mg of clavulanic acid. Both the first and the second methods of the dosage instructions are equally valid.
GlaxoSmithKline Company has mastered the production of so many different forms of the drug that an antibiotic can be easily prescribed for a patient of any age and weight. And search for new convenient doses is happening to this day. Thus, relatively recently it has been registered suspension for children Augmentin ES, that is designed for the treatment of severe infections, as well as for usage by older children.
The drug has almost an adult dosage of the active ingredients - 600mg of Amoxicillin and 42.9 mg of clavulanic acid. It should be noted that the package of the medication contains precisely calculated for a full course of treatment the number of pills. Thus, the minimum packing product contains 14 tablets and is designed for the scheme of therapy of uncomplicated infections. For long-term treatment there is a form of release of the 20 pills of Generic Augmentin in dosage of 625 mg and 400 mg.