Medical description: Generic Cefixime is an antibacterial substance for systemic usage. It is powder for suspension for oral accepting. The antibiotic is prescriber for curing of chronic and acute bronchitis, bacterial aggravation of bronchitis, inflammation of the middle ear, pharyngitis and tonsillitis bacterial etiology and bacterial urinary tract contagions: urethritis, cystitis, pyelonephritis and cervicitis.
Synonyms: Cefixx, Lupicef, Sefi, Sifi, Cefixoral, Cefspan, Cephoral, Oroken, Unixime
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care professional before using any drug.
Curative antibiotic Cefixime
Cefixime is an antibiotic that relates to the third generation cephalosporins, is distinguished by a wide range of antibacterial action. This is powder which is from white to pale yellow colour with a characteristic smell, while mixing this powder with water, you obtain from cream to pale yellow viscous suspension. Generic Cefixime destroys bacteria by disrupting the synthesis of the bacterial cell.
It interacts with penicillin connective proteins (SRP) in the cytoplasm of bacterial membranes and enzymes acetylate transpeptidase within the membrane, disrupting the transverse peptide chains that are required for building the bacterial cell. The antibiotic inhibits the growth and division of bacterial cells and causes lysis of the bacterial cell. Bacteria with high intensity divisions are particularly sensitive to the action of the drug. Cefixime is highly steady in the presence of beta-lactamase (penicillin basics and cephalosporinase), therefore, applies to a wide range of gram-negative bacteria, comprising strains that penicillin produces.
Mode administration, doses and side effects
People, who buy Generic Cefixime and want to prepare the suspension, should take purified and cooled to room temperature water (approximately 30-35 ml). You should open the bottle and pour into it (about 1/2 of its volume) water, close the bottle cap and shake. After that, open the bottle and add water to the mark on the bottle. Close the cap and shake well. Before every accepting this suspension should be thoroughly shaken.
Take orally. Apply before or after meals, when there is irritation of the digestive tract i.e. food. The suspension is appointed for use in pediatrics. For children from 6 months to 12 years old with body weight of 50 kg the usual dose is 8 mg/kg of body weight, which may be taken 1 time a day and 4 mg/kg body weight for 2 doses every 12 hours. The measuring device is designed for dosing suspension 100 mg/5 ml children, body weight which is from 1 to 25 kg (marks on the cylinder for each kilogram). For children from 6 months to 12 years old, the length of treatment depends on the seriousness of the disease and is determined individually. The course of the medical therapy is from 3 (uncomplicated infections) to 10-14 days.
Children, who weight more than 50 kg or older than 12, should be cured with doses that are recommended for grown-ups (400 mg 1 time per day or 200 mg per dose every 12 hours). The following negative reactions can be observed while you are treated with the antibiotic. Digestive tract: dry mouth, anorexia, nausea, dyspepsia, abdominal pain, mild diarrhea, intestinal spasms, flatulence; transient increase in liver transaminases and alkaline phosphatase, hyperbilirubinemia, jaundice, candidiasis mucous membranes of the mouth and digestive tract, dysbacteriosis; in some cases, stomatitis, glossitis, pseudomembranous colitis.
The circulatory system: platelet thrombocytopenia, leucopenia, eosinophilia, neutropenia, agranulosis; minor transient changes in liver and kidney samples, hemolytic anemia. Central nervous system: headache, fatigue, dizziness, hearing loss. Urinary system: interstitial nephritis, kidney function. Allergic reactions: rash, itching, urticaria, anaphylaxis, fever, arthralgia; in some cases, skin flushing, syndrome Stevens-Johnson syndrome and Lyell's syndrome. Other: vaginitis and genital pruritus.
Features of taking and interaction with other substances
If you are going to order Generic Cefixime, you should figure out whether there had been any earlier hypersensitivity reactions to cephalosporins or penicillins in patients in connection with cross-hypersensitivity to beta-lactams. The preparation should be appointed with caution in the presence of a history of bleeding disorders, gastrointestinal disease, especially regional enteritis, ulcerative colitis or colitis in applying the antibiotic (Cefixime can provoke pseudomembranous colitis) and also at infringement of function of a liver. Children with kidney disease are assigned from 1.5 to 3 mg of drug per 1 kg of body weight per day.
A long therapy course with Generic Cefixime can cause an outbreak of the growth of Candida albicans, and, as a result, candidiasis of the oral mucosa. In the presence of beta-hemolytic streptococcal contagions of group A, the therapy course should be at least 10 days to avoid acute rheumatic fever or glomerulonephritis. The prolonged treatment should monitor blood count and liver function of the kidneys. During the period of application of the drug can be a positive direct Coombs test, pseudo-positive reaction of the urine for glucose.
There is an influence on velocity responses while driving by motor transport or working with other mechanisms. There is a potential opportunity for increased nephrotoxicity while taking this antibiotic with other nephrotoxic drugs, such as strong diuretics, especially in examinees with violated renal function. The kidney function should be carefully controlled if a patient is treated with aminoglycosides simultaneously with Cefixime.
While applying Cefixime and carbamazepine increases the concentration of carbamazepine in plasma. The antibiotic may interact with zoomarine and other anticoagulants. Store at temperature not above 25 °C, protected from light and out of reach of children. The prepared suspension may be kept for 10 days at temperature above 25 ºC. Don’t cool and don’t freeze it. The bottle should be tightly closed.
Cefixime is an antibiotic helpful for the cure of a variety of bacterial contagions. It is a cephalosporin of the third generation.
Effectiveness of antimicrobial remedy Cefixime.
Generic Cefixime is an antibiotic that is consumed for the cure of infectious-inflammatory diseases caused by susceptible microorganisms: otitis media, tonsillitis, pharyngitis, sinusitis, chronic and acute bronchitis, uncomplicated gonorrhoea and uncomplicated urinary tract infections. The drug is described as effective and helpful for adults, teenagers and children.
If you buy Generic Cefixime, you should clarify whether you have hypersensitivity reactions to penicillins, cephalosporins or other drugs. When you use o Cefixime in examinees who are sensitive to penicillin, patients need to be careful because may develop cross-hypersensitivity among beta-lactam antibiotics (there are about 10% of patients that have a history of allergy to penicillin). If a person have allergic reactions to this antibiotic, it is necessary to cancel therapy. If there are serious acute hypersensitivity reactions, it may require the epinephrine and other emergency measures, including oxygen therapy, intravenous antihistamines, fluids, pressor amines, corticosteroids, mechanical ventilation.
Patients with diseases of the gastro-intestinal tract (especially colitis) should use the drug very carefully, as well as in those patients who have any allergies (especially to medications). After the prolonged usage of the antibiotic it is possible to get disruption of the normal intestinal flora, it can trigger the growth of Clostridium difficile and cause severe diarrhoea and pseudomembranous colitis. During the Cefixime therapy there may be probable false-positive reactions in urine glucose and positive direct Coombs test.
Is it safe for all the people?
In spite of its positive results, the drug isn’t helpful for everyone. There are some restrictions to its accepting, so before you are going to order Generic Cefixime, make sure that you have no chronic renal failure and pseudomembranous colitis. Old people and babies under 6 months aren’t recommended to use it.
During pregnancy, it is acceptable the possible use of Generic Cefixime if the predicted effects of treatment for the mother is above the possible risk to the fetus (well-controlled and adequate studies on the safety of use of the drug in pregnant women). In reproduction studies in rats and mice when administered doses that are up to 400 times the dose for a person, violations in the fetus have been identified. There is a necessity to stop breastfeeding during the Cefixime therapy.
Adverse effects and overdose.
Pay attention to the following side effects that you can mention during taking of Cefixime. Nervous system: dizziness, headache. Digestive system: stomatitis, nausea, diarrhea, abdominal pain, vomiting, transient increase in liver transaminases and ALP, pseudomembranous colitis. Blood: hemolytic anemia, eosinophilia, thrombocytopenia, leucopenia, neutropenia. Urogenital system: increased creatinine or urea nitrogen in serum, vaginitis and genital mycosis, there have been cases of interstitial nephritis. Allergic reactions: itching, skin rash, urticaria, erythema.
Overdose of Generic Cefixime increases adverse reactions.What to do: gastric lavage, supportive and symptomatic treatment, including glucocorticoids and antihistamines), oxygen therapy, mechanical ventilation; there is no specific antidote; when performing hemo - or peritoneal dialysis in large quantities Cefixime is not displayed.