Medical description: Generic Cefpodoxime belongs to the third-generation of cephalosporin antibiotics. It is proactive against a variety of Gram-positive and Gram-negative organisms. The arrangement of action of the medicament includes the violation of the synthesis of the bacterial cell wall. According the FDA Orange Book this drug is marketed as a generic medicine in the United States. It is usually applied to treat pharyngitis, acute otitis, sinusitis and gonorrhea. This preparation can be utilized as oral prolongation therapy when intravenous cephalosporins are no longer required for continued treatment.
Synonyms: Ceporex, Proxtl, Ancef, Biofuroksym, Ceclor, Cedax, Cefditoren, Cefizox, Cefotan, Ceftin, Cefurax, Cefuril, Cefuroxim, Cefzil, Duricef, Elobact, Fortaz, Keflex, Kefurox, Kefzol, Mandol, Maxipime, Mefoxin, Oraxim, Rocephin, Sharox, Tazicef, Velosef, Zinacef, Zinat
Consult your helth
care professional before using any drug.
How does Cefpodoxime act?
Cefpodoxime is an antibacterial preparation for the systemic usage in the medical practice. It is produced in the form of tablets that contain 100 or 200 mg of Cefpodoxime, in a LM envelope No. 10. and in the form of the powder in vials for the suspension preparation 50 mg/5 ml or 100 mg/5 ml (pediatric practice) No. 1. Composition: Tablets: Cefpodoxime, croscarmellose sodium, iron oxide, sodium chromalveolata, microcrystalline cellulose, silicon dioxide, magnesium stearate, Opadry OY-L white, sodium lauryl sulphate. Powder: Cefpodoxime, corn starch, citric acid, microcrystalline cellulose, simethicone emulsion, silicon dioxide, sucrose, hydroxypropyl cellulose, carboxymethylcellulose, saccharin sodium, dextrin, xanthan, flavoring vanillin, flavor with lemon.
After an oral taking Generic Cefpodoxime is imbibed in the small bowel and is hydrolyzed in the liver to form the active metabolite. Bioavailability of the antibiotic is about 50%, after the meal, the bioavailability of the drug increases. The maximum concentration in the blood is achieved within 2-3 hours. Cefpodoxime in moderation (up to 40%) is associated with blood plasma proteins. The drug penetrates well into most tissues and body fluids, especially in the parenchyma of the lungs, mucous membranes, bronchi, pleural fluid, tonsils and prostate.
Cefpodoxime crosses the placental barrier and is excreted into breast milk. Mainly the drug is excreted in urine unchanged and the period of decay is approximately 2.4 hours. During a standard 3 hour of hemodialysis session is removed from the body 23% of the dose. The absorption is shortened in examinees with cirrhosis of the liver. It cures infections of ENT-organs (pharyngitis, tonsillitis and otitis media), contagions of the lower respiratory tract, comprising acute exacerbation of chronic bronchitis, infectious bronchitis and pneumonia, contagions of soft tissues and skin, infectious diseases of the urinary tract, acute uncomplicated urethral, cervical and rectal gonorrhea.
Mode of administration, dosages and side effects
Cefpodoxime is used orally. Before it preparation, you need to turn and shake the bottle to fluff the powder, add cold boiled water to the mark indicated on the bottle, in two steps, each time shaking the vial until a homogeneous suspension forms. You can take suspension not earlier than 5 minutes after its preparation. The suspension is intended for usage in pediatrics. Children from 5 months to 12 years: 10mg/kg / day (maximum 200 mg per day) with an interval of 12 hours (maximum single dose -100 mg). It is admitted to use the antibiotic for pregnant women if there may be intended benefits for a mother and possible complications to an embryo or a fetus.
You shouldn’t take this antibiotic if you have hypersensitivity to the drugs group of cephalosporins, penicillins. Patients with hereditary galactose intolerance, lactase deficiency or syndrome malabsorb of glucose/galactose should avoid taking it.
Customers, who are going to buy Generic Cefpodoxime, should take into consideration the possibility of adverse effects. Fortunately, side effects are minor and occur only rarely. Among them can be: itching, gastro-intestinal tract, such as nausea, diarrhea, vomiting. Symptoms are: nausea, vomiting, epigastric discomfort and diarrhea. The treatment includes: hemodialysis or peritoneal dialysis, especially when kidney function and lavage.
Important information about Cefpodoxime
This preparation should be prescribed with caution in examinees with renal insufficiency. The dose is adjusted subject to a new creative ground clearance. The histamine H2-receptors (ranitidine, cimetidine, etc.) and antacids (aluminum hydroxide and sodium bicarbonate) reduce the fullness (but not rate) of absorption and Cmax of 27-32%. Oral anticholinesterase agents increase the intensity of absorption and the time to Cmax (47%). Probenecid inhibits renal excretion, increases the AUC by 37%, Cmax at 20%. Loop diuretics (furosemide, etc.) to increase (mutually) nephrotoxicity.
The prolonged usage of Cefpodoxime can lead to bacterial overgrowth and superinfection (candidiasis). When you order Generic Cefpodoxime and are going to take it with nephrotoxic drugs, it is recommended to control the kidney function. There is no information how this preparation influences velocity reactions in driving motor transport or operating other mechanisms. However, it is anticipated that while accepting of the antibiotic the risk of dizziness may occur, which can affect the capacity to drive or operate complex machinery. It is better to store dry powder at a temperature below 30 °C out of the reach of children; a ready suspension can be kept in the refrigerator and should be used within 14 days.
Cefpodoxime is a wide range antibiotic that is out of the group of cephalosporins of the third generation.
Cefpodoxime helps to overcome infectious diseases.
Generic Cefpodoxime is a b-lactam antibiotic of the third generation for oral administration. Its bactericidal effect is caused by inhibition of synthesis of bacterial walls of microorganisms. The drug is active against many gram-positive, gram-negative, aerobic and anaerobic microorganisms. The active ingredient of the drug is absorbed in the small intestine and is hydrolyzed to the proactive metabolite Cefpodoxime.
The maximum concentration in plasma is achieved within 2-4 hours after administration of a single dose. It binds to plasma proteins (mainly albumin), the connection with unsaturated type. Minimum inhibitory concentration (MIC) of the antibiotic for most pathogens is observed in the lung parenchyma, pleural fluid, bronchial mucosa, tonsils, interstitial fluid and the prostate. It penetrates kidney tissues.
Humans buy Generic Cefpodoxime for the treatment of contagious processes provoked by microorganisms sensitive to this antibiotic: sinusitis, tonsillitis, otitis, laryngitis, pharyngitis; bronchitis, pneumonia (severe forms of diseases – therapy effect of parenteral drugs); cystitis, pyelonephritis (mild to moderate); infections of skin, joints, bones, soft tissues; urethritis, proctitis, cervicitis gonococcal etiology.
Mode of administration.
The daily dose of Generic Cefpodoxime for adults and teenagers over 12 years old is 200-400 mg (for infections of the SDT and urinary tract infections 200 mg in pneumonia and / or bronchitis - 400 mg). Children from the age of 5 months Cefpodoxime is appointed in the daily dose equal to 10 mg/kg. This drug is taken simultaneously with food. The interval between doses is 12 hours. In severe impaired renal function (creatinine clearance < 40 ml / min) single dose of Cefpodoxime is reduced.
Side effects and contradictions.
While using the drug, you may experience the following side effects: nausea, abdominal pain, diarrhea, vomiting; headache; itching, transient rash; transient increase in liver transaminases; elevated levels of plasma creatinine and urea; eosinophilia; violations and thrombocytopoiesis.
The contraindications to the usage of the antibiotic are: hypersensitivity to the drugs group of cephalosporins, penicillins; hereditary galactose intolerance, lactase deficiency or malabsorption syndrome glucose / galactose; children under 5 months. Individuals, who usually buy or order Generic Cefpodoxime, are aware of possible overdosage. So, if you face the mentioned situation, you may feel such clinical manifestations as: nausea, diarrhea, vomiting. In this case the treatment is: gastric lavage, peritoneal dialysis and hemodialysis.