Generic Clarithromycin XL
Medical description: Generic Clarithromycin XL is primarily consumed to cure a lot of microbial contagions comprising: pneumonia, Helicobacter pylori and as an option to penicillin in strep throat. The drug was invented in 1980. Other usages comprise: cat scratch disease and other contagions owing to bartonella, cryptosporidiosis, as a second line agent in Lyme disease and toxoplasmosis. It may also be utilized to avoid bacterial endocarditis in those who cannot accept penicillin. Common adverse reactions include nausea, headaches vomiting and diarrhea. Serious allergic reactions are sparse.
Synonyms: Clamycin, Claymycin, Synclar, Clathromycin, Klacid, Klaricid, Macladin, Naxy, Prevpac, Veclam, Zeclar
Consult your helth
care professional before using any drug.
Clarithromycin XL is as an alternate to penicillin
Generic Clarithromycin XL is a semi-synthetic antibiotic of the macrolide group. It hinders protein synthesis in the microbial cell by interacting with the 50S ribosomal subunit of bacteria and acts primarily bacteriostatic and bactericidal. This drug is produced in the form of tablets which are coated. It is utilized during bacterial infections caused by susceptible microorganisms: infections of the upper respiratory tract (laryngitis, pharyngitis, tonsillitis and sinusitis), lower respiratory tract (bronchitis, pneumonia and atypical pneumonia), soft tissues and skin (folliculitis, furunculosis, impetigo and wound infection), otitis media; saying disease stomach and duodenal ulcers, mycobacteriosis, chlamydia.
The antibiotic is taken inside. Grown-ups and children over 12 years old take 250-500 mg twice a day. The duration of therapy is 6-14 days. In serious contagions or in case of oral accepting difficulty, the drug is prescribed in the form of injections at a dose of 500 mg/day for 2-5 days, with further transfer to the oral ingestion of 500 mg/day. The whole term of medical therapy is 10 days.
In the cure of contagions provoked by Mycobacterium avium, sinusitis and serious infections (involving those evoked by Haemophilus influenzae) it is appointed to take inside 0.5–1 g twice a day (the maximum dosage is 2 g a day). The length of treatment is 6 months or more. Patients with chronic renal failure should take 250 mg/day (once), in heavy infections the drug is prescribed 250 mg twice a day. The maximum duration of treatment in patients of this group is 14 days.
Adverse reactions and contradictions
When you are prescribed this medication by your medical specialist and you are going to buy Generic Clarithromycin XL, you should remember about side effects during taking the drug. Below you can find the list of commonplace side effects you’ll be able to face if you overdose. Nervous system: dizziness, headache, anxiety, fear, insomnia, "nightmare" dreams; rarely confusion, hallucination, psychosis, depersonalization, confusion.
Digestive system: nausea, gastralgia, vomiting, diarrhoea, stomatitis, glossitis, increased activity of, cholestatic jaundice, hepatic transaminases, rarely pseudomembranous enterocolitis. Senses: tinnitus, taste changes (dysgeusia); in a few cases — hearing loss, going after drug withdrawal. Hemostasis system and organs of hematopoiesis and hemostasis system: rare — thrombocytopenia (unusual bleeding, hemorrhage). Allergic reactions: itching, skin rash, malignant exudative erythema (syndrome Stevens-Johnson) and anaphylactoid reactions.
Other: development of resistance of microorganism. You are contradicted to take Generic Clarithromycin XL if you are hypersensitivity to the antibiotic components; if you have porphyria; if you are pregnant (I trimester); if you breast-feed; if you use of cisapride, pimozide and terfenadine simultaneously. The antibiotic is prescribed with caution to people who have renal and/or hepatic failure.
Pharmacokinetics, interaction and special instructions
Absorption is rapid. Food slows absorption, substantially without affecting the bioavailability. The connection with plasma proteins is more than 90%. After taking a single dose 2 peak of Cmax is registered. The second peak is due to the ability of the drug to concentrate in the gallbladder with subsequent entering the intestine and absorption. Cmax after oral taking of 250 mg is reached after 1-3 hours The regular intake of 250 mg/day equilibrium concentrations of unchanged drug and its main metabolite is 1 and 0.6 µg/ml, respectively; T1/2 is 3-4 and 5-6 h, respectively.
When increasing doses up to 500 mg/day equilibrium concentration of unchanged drug and its metabolite in plasma and 2.7–2.9 and 0,83–0,88 g/ml, respectively; T1/2 — 4,8–5 and 6.9 to 8.7 hours, respectively. At therapeutic concentrations it is accumulated in the lungs, skin and soft tissues (the concentration is 10 times higher than the level in the serum). The preparation is excreted by kidneys and feces (20-30% in an unmodified form, the rest is excreted in the form of metabolites). In single dose of 250 and 1200 mg it is excreted by kidneys and 37,9% and 46%, with feces — 40,2 and 29.1%, respectively.
If you order Generic Clarithromycin XL, you should take into consideration that it isn’t allowed concurrent use with cisapride, pimozide, terfenadine. During the simultaneous taking of these drugs, it may raise the blood concentration of drugs metabolized in the liver by enzymes of the cytochrome P450, indirect anticoagulants, carbamazepine, theophylline, astemizola, cisapride, terfenadine (2-3 times), triazolam, midazolam, cyclosporine, dizopiramida, phenytoin, rifabutin, lovastatin, digoxin, ergot alkaloids, etc. The drug reduces the absorption of zidovudine (an interval of at least 4 hours is required between taking drugs).
It is possible of the development of cross-resistance between Clarithromycin, Lincomycin and Clindamycin. The systematic control of serum enzymes blood is necessary in the presence of chronic liver disease. Generic Clarithromycin XL is appointed with caution amid drugs that are metabolized by the liver (it is advised to quantify their concentration in the blood). The prothrombin time must be controlled in the case of a joint appointment with Warfarin or other indirect anticoagulants. If there are heart diseases in anamnesis, it isn’t advised to have a simultaneous accepting with terfenadine, cisapride and astemizole.
Clarithromycin XL is an antibiotic useful to cure a lot of bacterial contagions. It involves strep throat, pneumonia and infections of skin.
Generic Clarithromycin XL
Clarithromycin XL fights with infectious diseases.
Generic Clarithromycin XL is a macrolane antibiotic consumed to cure pharyngitis, tonsillitis, acute sinusitis, acute bacterial or chronic bronchitis, pneumonia (especially atypical pneumonias connected with Chlamydia pneumoniae or TWAR), infections of skin and in examinees with HIV/AIDS, infection with Mycobacterium avium complex (MAC). In addition, the medication is sometimes utilized to cure legionellosis.
Unlike Erythromycin, changing the structure of the molecule resulted in greater bioavailability of Clarithromycin, stability in an acidic environment, has increased the concentration in the tissues, extends the antimicrobial spectrum, extended the period of floor removal, which allowed prescribing the drug twice a day, and thereby improving the treatment process.
As Erythromycin, Clarithromycin suppresses the microbial cell protein synthesis by interacting with the 50 S subunit ribosomal of microbial cell membrane. The drug is resistant to beta-lactamases, and therefore it exhibits a high activity against a broad spectrum of aerobic and anaerobic gram-positive and gram-negative microorganisms. Clarithromycin is active against most strains of such microorganisms: gram-positive aerobes, gram-negative aerobes, mycobacterium other microorganisms.
Mode of administration, doses and possible side effects.
Patients usually buy Generic Clarithromycin XL when this antibiotic is prescribed by their medical specialist. The average dose is 250 mg 2 times a day for adults and children over 12 years old. If there is a necessity, Clarithromycin XL can be appointed to take 500 mg twice a day. The duration of treatment is 6-14 days. For the treatment of infections caused by Mycobacterium avium, the antibiotic is appointed 1 twice a day.
The treatment duration may be 6 months and more. The daily dosage for children from 4 to 12 years old is 7.5 mg/kg of body weight; the maximum daily dose of 500 mg. The duration of treatment is 7 — 10 days. Among possible adverse reactions you can find the following ones: nausea, vomiting, pain in epigastric area, diarrhea and transient increase in liver transaminases, skin rash and headache. The urgent maintenance therapy should be carried out in case of allergic reactions or hypersensitivity reactions. During the treatment with Generic Clarithromycin XL there may be superinfection caused by resistant bacteria or fungi, in this case it is necessary to refuse a medical therapy.
Dennis: My doctor prescribed me this antibiotic, but I couldn’t find it in the drugstores, so I was advised to order Generic Clarithromycin XL on the Internet. I started my treatment and the effect was positive. I had no bitterness or other negative indications. In addition, my physician prescribed me extra preparations in order to avoid permissible negative reactions. Don’t take any antibiotics without a health care professional’s recommendation. It may do harm to your health.
Rose: Human organisms are different and side effects are also various for everyone. Someone withstand the treatment with this drug, someone can get serious health problems. Your doctor should take into consideration all your organism’s peculiarities and only then appoint the antibiotic. In my case Generic Clarithromycin XL was effective. It helped me to overcome acute bacterial bronchitis.
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