Medical description: Minocycline is the broadest-spectrum tetracycline antibiotic used for the treatment of various infections. It is a semi-synthetic drug derived from the natural antibiotic agent in 1966. The drug is commonly prescribed as an alternative to penicillin antibiotics in people allergic to penicillin. The medicine is considered relatively safe and can be administered to children older than 8 years. The daily dosage for adults is 50-100 mg. For children, the dosage should be calculated based on the body weight for each child individually.
Synonyms: Minoz, Arestin, Dynacin, Klinomycin, Vectrin
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The broadest-spectrum antibiotic medicine from the group of Tetracyclines was first synthesized in 1966. The medicine is currently known as Minocycline. The drug is effective both against Gram-positive and Gram-negative bacteria, including meningococci. Minocycline differs from the other Tetracyclines also in the half-life period. It is considered a long-acting type tetracycline meaning that the concentration of the drug in blood serum is increased during longer time compared to other drugs from the class. This feature results in lower dosages of the medicine taken daily.
Upon the medicine’s discovery by Lederle Laboratories in 1966, the medicine was patented as Minocin. Currently, since the patent had already expired, the medicine is made by various pharmaceutical companies that use different trademarks for it. Minocycline can be found at the international drugstores as Minostad, Arestin, Minoderm, Dynacin, Akamin, and many other different names depending on the pharmaceutical company that manufactures the drug. Online you can find the medicine with Minocycline as an active substance looking for Generic Minocycline. The dosages of the active substance per pill do not differ, so regardless of which manufacturer you choose, you will get the same medicine.
Minocycline - Mode of action
Minocycline has the same mechanism of bacteriostatic effect as other tetracyclines. It prevents further bacteria growth and replication causing reversible inhibition of protein synthesis in the pathogen cells. The medicine penetrates the lipid bilayer of the bacterial membrane and binds to the 30S-ribosomal subunit. Doing so, it blocks the attachment of transfer RNA to it making the synthesis of bacterial proteins impossible.
Minocycline – pharmacokinetics
The maximum concentration of Minocycline active substance is observed in serum in 1 to 4 hours after the medicine intake. The average concentration of Minocycline observed is 3.5 µg/ml. Minocycline is metabolized in the liver and is excreted from the body in 11 to 22 hours. The half-life of Minocycline in people with liver insufficiency is unchanged.
However, in kidney dysfunction, the complete excretion of the medicine is done in 18 to 69 hours.
When Minocycline is prescribed
Minocycline is used for various infectious diseases such as skin infections, including acne, urinary tract infections, respiratory tract infections, tick fever, gonorrhea, Chlamydia, structure infections, soft tissue infections, and others. The medicine is highly soluble in water, so for some infection localizations it can be ineffective. Before prescribing the medicine, it is always preferable to conduct susceptibility study first to be sure that the infection is caused by the bacteria sensible to Minocycline.
Minocycline can replace penicillin antibiotics in the treatment of patients allergic to penicillin.
The release form of Minocycline
Most manufacturers of Minocycline supply the drug in 50 or 100 mg capsules for oral intake. These pills are immediate-release formulations. There are also extended-release tablets that differ in the intervals between the intakes. This feature must be specified when your doctor prescribes you Minocycline.
Dosages of Minocycline
The following dosages are for Minocycline of the immediate-release formulation.
Generally, adult patients are prescribed to take 100-200 mg of Minocycline a day for any acute infectious process induced by a susceptible pathogen. The length of the treatment course is chosen individually for each patient. Patients with kidney dysfunction require a dosage adjustment.
General recommendations are the following:
Acne treatment - from 3 to 6 weeks.
Actinomycosis treatment – the daily dosage 100 mg of the drug should be taken every 12 hours for 6 to 12 months.
Meningitis therapy (carrier state) - 100 mg of Minocycline every 12 hours for 5 days.
Skin, soft tissue or structure infection treatment - 100 mg of Minocycline every 12 hours for 3 months.
Children over 8 years of age should be administered 4 mg per kilogram of the body weight in the first intake and 1-2 mg per kilogram of the child’s body weight every following 12 hours. The treatment of acne in children is done for 12 weeks. The length of the treatment course of bacterial infection of other localization is prescribed by a doctor.
Interactions with other medicines
Before using Minocycline, a doctor prescribing the drug must be sure that the patient is not using any drugs that negatively interact with the antibiotic. Minocycline badly interacts with: anticoagulant medicines, penicillin antibiotics, isotretinoin, antacids, methoxyflurane, and their analogs. Hormonal contraceptives are known to be less effective if combined with Minocycline.
Some interactions result in the reduction of the medicines effect, others may cause irreversible harm to the patient’s body and even fatality.
Contraindications for Minocycline use
Primarily, the medicine is contraindicated to people allergic to any of tetracycline antibiotics or additional substances contained in the pills or solution for intravenous infusion.
Minocycline is also contraindicated in severe hepatic and renal failure, lactose intolerance, leucopenia, systemic lupus erythematosus, and porphyria.
The antibiotic is also contraindicated to pregnant and breastfeeding women and children less than 8 years of age.
Adverse effects of Minocycline
Minocycline may cause the occurrence of common side effects that are usual in the use of majority of modern antibiotics such as diarrhea, tiredness, fever, upset stomach, nausea, fatigue, dizziness, general weakness, etc. Such adverse reactions tend to vanish quickly after the treatment course is terminated or with a help of medicines for digestion or painkillers. Worth noting though that there are also severe side effects that can seriously damage the central nervous system, kidneys or cause trouble breathing, seizures, and other dysfunctions. Such severe adverse effects are extremely rare, but a doctor’s supervision and cautious intake of the medicine are always preferable in order to identify potential risk timely.
Minocycline or Generic Minocycline is used for various infectious diseases such as skin infections, urinary tract infections, tick fever, and others.
Any infection needs antibiotic therapy to be completely eliminated. The best way to choose the right antibiotic for the infection you have is to make a susceptibility study first. Though most of the modern antibiotics are broad-spectrum ones, there are always exceptions. For example, a certain antibiotic can be effective against all strains of Streptococcus, but is ineffective against Staphylococcus strains. Naturally, if the susceptibility test shows that the infection you have is caused by Staphylococcus, that certain medicine will be ineffective.
Probably, namely due to this reason all antibiotics in the United States are sold with a prescription only. However, if you are sure that you need, for example, Minocycline, but do not have a prescription for it or have it but want to buy it cheaper than your local drugstores offer, you can buy its cheaper versions online looking for Generic Minocycline.
How does Generic Minocycline differ from the brand drug?
Generic medicines are the medicines absolutely identical by composition and effect to the brand drugs. They are named differently because they are manufactured and registered by the other pharmaceutical companies. If you find a reliable seller who sells authentic Generic Minocycline and not a placebo, you will get the same treatment for the price up to ten times cheaper than the local U.S. pharmacies offer. High prices of the medicines sold in the U.S. do not mean that the medicines are more potent or safe. They are so high because of the production costs, government regulations, taxes, costly registration process, expensive advertising, and so on. Moreover, if the medicine was discovered or synthesized by an American company, the cost of the research is included in the price of the medicine while other pharmaceutical companies are able to use already ready formula and sell the same drugs cheaper. It may seem unfair, but this way you can have an effective treatment with Generic Minocycline or any other generic medicine even if you have a small income.
How to buy Generic Minocycline online safely?
First of all, use the service of a trustworthy online pharmacy. Check the pharmacy we recommend on the main page, we have already checked it and can certainly say that there you can find the best Generic Minocycline with sufficient shelf life and right doses per pill.
How to use Generic Minocycline?
The dosage of Generic Minocycline should be the same as that of Minocycline. However, make sure to buy the pills of the correct dosage and pay special attention to whether the drug is of the immediate-release or extended-release formulation. The formulation you need depends on the type and severity of infection you have as well as whether it is acute or chronic.
The general dosage of the Generic Minocycline immediate-release pills for adults is 100-200 mg a day. The length of the treatment course for acne vulgaris is from 3 to 6 weeks; actinomycoses requires the course of 6 to 12 months during which the pills of 100 mg are taken every 12 hours; carriers of meningitis are prescribed Generic Minocycline 100 mg every 12 hours during 5 days; soft tissue or structure infections are treated for 3 months by intake of 100 mg of the drug every 12 hours.
Dosages of Generic Minocycline for children are calculated individually based on the body weight. The drug can be administered to children older than 8 years in the dosage of 4 mg per kilogram of the body weight at the first intake and by 1-2 mg per kilogram of the body weight after 12 hours. The next dosages during the entire treatment course must not exceed 1-2 mg per kilogram of the child’s body weight given every 12 hours.