Medical description: Moxifloxacin a synthetic fluoroquinolone antibiotic medicine approved in the USA in 1999. It is a fourth-generation antibiotic from the class with an increased activity against Gram-positive and anaerobic bacteria. In other countries the medicine can be found under other trademarks and various forms such as pills, solution for intravenous infusion, eye drops, and ointment for skin infections. Moxifloxacin is used in adults exclusively. Its daily dosage in the treatment of any infection sensible to the active substance of the drug is 400 mg both in oral or intravenous administration.
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Moxifloxacin is an antibiotic medicine used since 1991 worldwide and since 1999 in the United States of America upon the approval of FDA. Moxifloxacin is a synthetic fluoroquinolone antibacterial drug of fourth generation first synthesized by pharmaceutical company Bayer AG. With the improvements made, the fourth generation fluoroquinolone antibiotic is more effective against Gram-positive pathogens and anaerobic bacteria. Besides that, Moxifloxacin is effective against Gram-negative bacteria and atypical bacteria. Being ranked 140 in the rating of 200 of top prescribed medicines in the United States for 2007, the medicine is included in the List of Essential Medicines of World Health Organization. Worldwide the medicine can be found under various brand names and forms of release. For example, in the USA the pills are called Avelox, Avalox, and Avelon, eye drops are called Vigamox and Moxeza. In other countries it can be called Tevalox, Moximac, etc.
Moxifloxacin - Mechanism of action
When used in any of forms, Moxifloxacin generally or locally inhibits DNA gyrase, a type II topoisomerase, and topoisomerase IV, the enzymes responsible for bacterial DNA transportation and their cells development.
Chemical properties of Moxifloxacin
The active ingredient of the medicine, Moxifloxacin monohydrochloride, is a crystalline substance of slightly yellow or yellow color.
Pharmacokinetics of Moxifloxacin
When used orally, Moxifloxacin is almost completely absorbed regardless of the time of meal intakes. The bioavailability accounts to 90%. High concentrations of the medicine are found in the lungs, alveolar macrophages, bronchial mucosa and sinuses. The medicine is excreted in urine and feces unchanged. The excretion of 45% of the medicine is unchanged in the patients with liver or kidney dysfunctions. The half-life of the medicine is from 11.5 to 16.6 hours. The pharmacokinetics of Moxifloxacin in children was not studied.
When Moxifloxacin is prescribed
Primarily, the medicine is prescribed for respiratory tract infections treatment because of its high effectiveness against common respiratory pathogen Streptococcus pneumonia.
Indications for Moxifloxacin use are the following: in the United States the medicine is approved and commonly prescribed for acute bacterial exacerbation of chronic bronchitis, acute bacterial sinusitis, community acquired pneumonia, complicated and uncomplicated skin and soft tissue infections, and complicated intra-abdominal infections. In the European Union, the medicine is approved for the same conditions but with certain specifications, for example, it is advised only in uncomplicated community-acquired pneumonia.
Release form of Moxifloxacin
The most commonly prescribed form of the medicine in case of outpatient treatment is 400 mg pills. In case of hospital treatment, intravenous infusions from vials of 400 mg can be used.
Besides two forms for the general treatment plans, Moxifloxacin is released in form of eye drops for eye infections such as conjunctivitis and in form of ointment used for skin infections such as acne or cellulitis.
Dosages of Moxifloxacin and lengths of the treatment courses
Dosages of Moxifloxacin for various diseases in adults are similar; however, the lengths of the treatment courses greatly vary. The following dosage and treatment course recommendations are for adults only.
Exacerbation of chronic bronchitis requires the use of Moxifloxacin 400 mg orally or intravenously (through drip) every 24 hours for 5 days.
Treatment course for uncomplicated pneumonia requires the intake of Moxifloxacin 400 mg daily orally or through drip for 7-14 days.
For the treatment of intra-abdominal infections, Moxifloxacin 400 mg is taken daily orally or intravenously through for 5 to 14 days.
Treatment course of sinusitis requires the intake of Moxifloxacin 400 mg daily orally or intravenously through a drip for 10 days.
Skin and structure infections are treated by Moxifloxacin 400 mg administered orally or intravenously every 24 hours. The length of the treatment course depends on whether the infection is complicated or not: uncomplicated infections are treated for 7 days, complicated for 7- 21 days.
In general, the dosage is the same for every treatment plan and prophylaxis. Differs the length of the treatment course which can vary from 7 to 60 days and list of drugs taken simultaneously. For example, in active tuberculosis Moxifloxacin is prescribed as a second-line drug.
Ointments and eye drops are applied locally in the amount recommended in the instruction coming with the medicine. The treatment course length and numbers of daily applications differ from the dosage of the active substance in the solution or the ointment.
When to take Moxifloxacin
The medicine can be taken without any regard to meal intake as its bioavailability is not affected by food.
The medicine is contraindicated to people allergic to the medicine or other fluoroquinolone antibacterial agents. It is also contraindicated to children, people prone to epileptic seizures occurrence, people with the history of tendon disorder, patients with uncorrected hypokalemia, pregnant and breastfeeding women.
The medicine is used with caution in patients with diabetes and cardiovascular diseases.
The medicine is considered to be potentially harmful in drug interaction with nonsteroidal anti-inflammatory drugs. Combination of the medicine with corticosteroids increases the risk of disability development. Antacids prevent the full absorption of the medicine.
Moxifloxacin can cause a variety of side effects including allergic reactions such as hives, skin rash, difficult breathing, and swelling of lips, throat or tongue. These side effects may develop overtime so you have to be attentive and immediately seek medical assistance when you first notice them as they may lead to fatality. Other side effects include nausea, diarrhea, headache, dizziness, sore throat chills, etc. The specific side effect of the drug is possible damage to nerves or tendon rupture. If you notice numbness in any part of your body, sudden pain, bruising swelling, movement problems, tingling, burning pain, etc., you should immediately stop using the medicine and seek medical assistance.
Moxifloxacin is a synthetic fluoroquinolone antibacterial drug of fourth generation first synthesized by pharmaceutical company Bayer AG.
Antibiotic drugs are essential for bacteria treatment. Though all of them are critically important in the modern medicine, some of them are more potent and some are less. You may ask yourself, why do the less effective drugs are on the market then if there are more effective ones already? The answer is simple, not all infections require the use of broad-spectrum high bioavailability medicines. Naturally, those medicines with narrower range of efficiency are cheaper. If you have a mild infection and your doctor prescribes you a cheap antibiotic drug, it is fine. Probably, you do not need a potent medicine.
Since you are viewing this page, you are, probably, looking for Generic Moxifloxacin. Note that it is not a narrower spectrum antibiotic if it’s named generic. Generic medicines have absolutely the same properties as the brand drugs with the same active ingredient, so Generic Moxifloxacin is effective against absolutely the same bacteria and illnesses as the brand Moxifloxacin. The medicines we referred to as less potent are the antibiotics of previous generations while Generic Moxifloxacin is a fourth-generation fluoroquinolone antibiotic highly effective against a wide range of pathogens including those causing plague, tuberculosis, pneumonia, recurring bronchitis, and so on. Worth noting, though, that Generic Moxifloxacin is cheaper than Moxifloxacin like those old antibiotics. It can be cheaper when it is manufactured by other companies who were not its discoverers. Being able to use already found formula without spending millions on research and not entering the monopolized U.S. market, these pharmaceutical companies sell their products twice or thrice cheaper. Generic Moxifloxacin is used all over the world and can be bought under a variety of trademarks. But if you live in the USA you cannot buy it at your local drugstore, unfortunately. Read further to know how you can purchase the drug you need cheap without leaving your country and going for a hunt for international versions of Moxifloxacin.
How to buy Generic Moxifloxacin?
Online pharmacies offer you an amazing possibility to buy the international versions of the medicines available in the US several times cheaper. It can be challenging finding a reliable online store. We recommend you to use one of the links from our website. We share links to the pharmacies we work with for a long time already. We value our reputation so we have already checked our partners offering Generic Moxifloxacin for trustworthiness.
How the use of Generic Moxifloxacin differs from the use of brand Moxifloxacin?
Most of the time, the medicines with the same active substances are released in the same dosages per pill regardless of the manufacturer, but it would not hurt to double check the dosage of Moxifloxacin per pill before placing the order. The daily dose of the medicine for adults whom the medicine is not contraindicated is 400 mg daily throughout a treatment course from 7 to 60 days depending on the condition treated and severity of infection. Make sure to buy Generic Moxifloxacin 400 mg in order to be sure that you are using the drug you need.
Worth noting that Generic Moxifloxacin can also be sold in vials for intravenous infusions, ointment or eye drops. Make sure to check the release form and choose the one you need for your treatment course.
If you have already bought the medicine, remember that careful use is the key to a successful treatment. Taking bigger dosages of the medicine will not make you get well sooner. On the contrary, they can worsen your state of health.