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Generic Roxithromycin

Medical description: Roxithromycin is an antibiotic drug prescribed for the treatment of upper and lower airways infections, urinary infections, chronic bone infectious diseases, and others. The common dosage of the medicine is 300 mg per day consumed in two takes in the morning before meal and in the evening before meal by 150 mg. In liver failure the dosage is 150 mg of Roxithromycin a day. The dosage for kids is chosen individually based on the weight and severity of the infection. The medicine can cause a number of adverse effects; therefore, its use requires medical supervision. It is prohibited to use the drug during pregnancy and in breastfeeding women.

Synonyms: Cadithro, Raxitid, Roxigin, Roxipic, Roxpic, Surlid

Generic Roxithromycin
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Consult your helth care professional before using any drug.

Medication guide:

Roxithromycin is the first created semisynthetic 14-membered macrolide. It is an antibiotic drug derivative from erythromycin. It has the same 14-membered lactone ring, but additionally N-oxime side chain which lacks in erythromycin.

The medicine was first launched in 1987 by the German pharmaceutical company Hoechst Uclaf. Currently, the medicine is manufactured and marketed in many countries under different registered names: Acevor in Greece, Ai Luo Xin in China, Aparox in Pakistan, Arrow Roxithromycin in New Zeland, etc.

Indications for the Roxithromycin use

The medicine is mostly prescribed to treat upper and lower airways infections and other diseases treated by otolaryngologist such as pharyngitis, bronchitis, pneumonia, bacterial infections in patients with chronic obstructive pulmonary disease, panbronchiolitis, bronchiectasis, tonsillitis, sinusitis, and otitis media. It is also used urinary disorders associated with infections such as urethritis, endometriosis, cervicitis, vaginitis, including sexually transmitted infections other than gonorrhea.  In inflectional soft tissue diseases such as erysipelas, boils, folliculitis, impetigo, and pyoderma Roxithromycin is also prescribed.

Some doctors find the medicine helpful in the treatment of bone diseases such as periostitis and chronic osteomyelitis. Roxithromycin has also shown its efficiency in the treatment of scarlet fever, diphtheria, whooping cough, trachoma, migratory erythematous rash, brucellosis. It is also used to prevent meningococcal disease in those who have been in contact with infected.

The medicine is also used in dentistry to treat periodontitis and prevent bacteremia development after dental surgery in patients with endocarditis.

Roxithromycin - Mechanism of action

Stopping the protein synthesis in bacteria by attaching to the bacterial RNA and thus inhibiting the translocation of peptides, Roxithromycin prevents bacterial growth. Roxithromycin is a wide spectrum antibiotic as well as erythromycin, but it has shown more efficiency against some Gram-negative bacteria and, therefore, is considered more potent.

Chemical properties of Roxithromycin

Molecular formula of the drug is C41H76N2O15.

Pharmacokinetics of Roxithromycin

The medicine is advised to be taken on an empty stomach before and not after meals as this way it is absorbed quite quickly into tissues and phagocytes (the body cells that protect the body by “swallowing” harmful particles), next, rapidly transported to the main infection centre.

Most part of consumed Roxithromycin is excreted unchanged into the bile and some in expired air. Less than 10% is excreted with urine. Only a small part of the medicine is metabolized in the body.

The release form of Roxithromycin

The medicine is supplied in coated or simple tablets for oral use dosed 150 mg. Some pharmaceutical companies also supply suspension for children that comes in a 50-milliliter bottle.

Prescribed Dosages of Roxithromycin

The tablets of Roxithromycin are prescribed to adults as follows: 150 milligram pill two times a day in the morning and in the evening before meal or 300 milligrams (two pills) at once in the morning or in the evening. In hepatic insufficiency, the daily dose is reduced to 150 milligrams a day.

For children, the dosage of Roxithromycin suspension is 5-8 milligrams per kilogram of body weight a day. The dosage per kilogram depends on the body weight, bacteria, and severity of infection. It is not advised to use the medicine in children with the body weight less than 40 kilograms.

The length of the treatment course is prescribed by a doctor, however, there are recommended lengths for each type of infection treated with Roxithromycin:

-    From 5 to 12 days for respiratory tract diseases
-    From 2 to 2,5 months in chronic osteomyelitis
-    14 days in Mycoplasma pneumonia or Chlamydia pneumonia-induced diseases
-    Up to 21 days in pneumonia caused by Legionella

For children, the maximum recommended treatment course is 10 days.

Contraindications for Roxithromycin use

The medicine is contraindicated to be used in patients with hypersensitivity to it or erythromycin. It is also contraindicated to pregnant or breastfeeding women and children under two months of age. It should be carefully taken in hepatic insufficiency.

Roxithromycin better interacts with other medicines than erythromycin, but is also contraindicated to be used with Ergotamine, Dihydroergotamine, and Warfarin or other medicines with the same active ingredient.

Adverse effects of Roxithromycin

As well as other medicines and especially antibiotics, Roxithromycin can cause a wide range of side effects. However, most of them occur either in hypersensitivity to the active substance or as a result of misuse of the medicine. Most common possible side effects of Roxithromycin are:

-  decreased appetite, heartburn, jaundice, vomiting, epigastric distress, nausea, flatulence, diarrhea, pancreatitis, pseudomembranous enterocolitis
-  abnormalities in liver function, cholestatic or hepatocellular acute hepatitis
-  fever, headache, sleepiness, fatigue, dizziness, inability to concentrate, muscular weakness, bronchial spasm
-  flushing, itching, rash, angiooedema, anaphylaxis
- alteration in senses of smell and taste
- vaginal and oral candidiasis

Measures in overdose of Roxithromycin

In overdose of the medicine, immediate medical assistance is required. When a patient takes a dosage of Roxithromycin that significantly exceeds the prescribed one, the gastric lavage is performed and symptomatic treatment prescribed. There is no specific antidote to neutralize the antibiotic in the excess of the dose prescribed.
In case of any of Roxithromycin side effects manifestation, medical consultation is also required.

Roxithromycin is one of the most used antibiotics for respiratory tract infectious diseases. Find out the dosages and contraindications before starting usi


 

Generic Roxithromycin

We are a fortunate generation of people who have access to the medicines that cure almost any disease. The even more amazing fact is that all of them, for example, antibiotics, are aimed to eliminate certain types of bacteria guaranteeing that they in fact kill them as they were made and tested for this rather than give us blind trust in sheer luck.

The most common infection diseases today in first world countries are respiratory and urinary tract illnesses caused by various bacteria. Though there are various bacteria, the said parts of our body are most likely to be attacked by certain types of them. These types of bacteria are successfully treated today with Roxithromycin, an antibiotic used specially for airways and urinary tract infections. Worth noting, however, that the medicine is also used to treat bone diseases such as periostitis and chronic osteomyelitis. It also shows high efficiency in prevention of meningitis in people who have been exposed. Dentists prescribe their patients Roxithromycin in order to avoid bacteremia in patients with endocarditis and treat periodontitis.

How to choose the right dosage of Generic Roxithromycin?

Unlike for other antibiotics, the dosage of Generic Roxithromycin can be easily calculated: in healthy liver all adult patients are prescribed to take two pills of the medicine two times a day before meal. First pill should be taken in the morning and the second in the evening. The dosages are the same for all infections treated with the drug. However, the treatment courses lengths are different: for respiratory tract diseases the course is between 5 to 12 days, in chronic osteomyelitis - from 2 to 2,5 months, in Mycoplasma pneumonia or Chlamydia pneumonia pills are taken for 14 days, in pneumonia caused by Legionella, the course can be prolonged up to 21 day.

For children the dosage is calculated in a bit more difficult manner. It is contraindicated to give pills to children before two months of age or under 40 kilograms (88 pounds) of body weight. The dosage of Generic Roxithromycin suspension is calculated based on the bacteria that caused the disease and the severity of infectious process and is from 5 to 8 milligrams of the medicine per kilogram of weight a day. The treatment course must not exceed 10 days.

In liver failure the daily dosage of the medicine is cut in two. In manifestation of any adverse reaction the treatment course should be terminated.

Contraindications and possible side effects from the use of Generic Roxithromycin

The medicine is contraindicated to people with individual hypersensitivity to the main component of the drug. It is also prohibited to use the drug during the pregnancy or breastfeeding period and in combination with Ergotamine, Dihydroergotamine, and Warfarin.

The adverse reactions Generic Roxithromycin can cause are: decreased appetite, heartburn, epigastric distress, nausea, vomiting, flatulence, diarrhea, pancreatitis, pseudomembranous enterocolitis, cholestatic or hepatocellular acute hepatitis, sleepiness, fatigue, dizziness headache, alteration in senses of smell and taste
Allergic reactions may include rash, flushing, itching, angiooedema, bronchial spasm, and anaphylaxis.

The use of medicine without antifungal medicines may result in the development of vaginal and oral candidiasis.

Disclaimer

The article on Generic Roxithromycin is for information only. Before using the medicine you must consult your doctor and observe the dosages prescribed by him even if they do not correspond to the medicine instruction provided on this webpage or inside the drug package.

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