Medical description: Rulide is an antibiotic used primarily to treat upper and lower airways and urinary infections. It is also used to treat inflammatory processes in soft tissues caused by bacteria sensitive to the main drug ingredient.
The medicine is a derivative from erythromycin with a wider spectrum of action, lower negative interaction with other medicines and more pronounced effect against certain Gram-negative bacteria.
The medicine is released in 150 milligram tablets that should be taken twice a day on an empty stomach.
Synonyms: Cadithro, Raxitid, Roxigin, Roxipic, Roxpic, Surlid
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care professional before using any drug.
Rulide is a brand name of the medicine based on the active substance called Roxithromycin. It is a semisynthetic antibiotic medicine that was first marketed in 1987 by Hoechst Uclaf, German pharmaceutical company.
The active substance of the medicine is 14-membered macrolide derived from erythromycin. It consists of the same 14-membered lactone ring as erythromycin but has an additional - N-oxime side chain.
Besides the name Rulide, the medicine bears other names: in Greece – Acevor, Delitroxin, Anti-Bio, Bazuctril, and others; in Germany – Roxithromycin, Roxithromycine, Roxi Aristo, and others; in India – Emrox, Genrox, Inrox; in Argentina – Delos, etc.
Indications for the Rulide use
Rulide is an antibiotic that is mostly effective in the treatment of wide-spread upper and lower respiratory tract infectious diseases and other diseases treated by otolaryngology specialists such as bronchitis, pneumonia, pharyngitis, tonsillitis, sinusitis, bacterial infections in patients with chronic obstructive pulmonary disease, panbronchiolitis, bronchiectasis, and otitis media.
Rulide and other medicines with the same composition are also used to treat urinary infections and diseases such as endometriosis, urethritis, vaginitis, cervicitis, including sexually transmitted infections except gonorrhea. It is also effective in the treatment of soft tissue infectious diseases such as erysipelas, boils, impetigo, folliculitis, and pyoderma.
Rulide is also frequently prescribed for the treatment of some bone diseases such as periostitis and chronic osteomyelitis. The medicine is used also in dental medicine to treat periodontitis and prevent bacteremia in patients with endocarditis after dental surgery. It is also used as a prevention measure in patients who have been exposed to meningococcal disease.
Other indications for use of Rulide include diphtheria, scarlet fever, trachoma, pertussis, migratory erythematous rash, and brucellosis.
Mechanism of action of Rulide
The medicine prevents bacteria molecules growth by attaching to the bacterial RNA and, therefore, inhibiting the translocation of peptides.
Pharmacokinetics of Rulide
In the intake on an empty stomach, the medicine is promptly absorbed into the body tissues and phagocytes through which it is quickly transported to the main infection centre. Only small part of Rulide is metabolized in the body. The most share of consumed medicine leaves the body in an unchanged form through the bile and expired air, and about 10% is excreted with urine.
Form of Supply and Prescribed Dosages of Rulide
Rulide is manufactured in form of tablets for oral use 150 mg each and suspension for use children supplied in 50 milliliter bottles.
Adult patients, regardless of the infection treated, are recommended to take 150 milligram tablets two times a day. First tablet should be taken in the morning before breakfast and second in the evening before dinner or two hours after the last meal of the day. Sometimes it is advised to take two pills at once either in the morning or in the evening; though it is necessary to take them before meals as in this way the medicine provides much more potent effect.
Patients with liver failure should take the lower dosage that constitutes only one tablet of Rulide 150 milligrams a day.
For use in children the dosage of Rulide suspension is calculated based on the patient’s weight. Per kilogram of a child’s weight from 5 to 8 milligrams a day are recommended. The daily dosage for children per kilogram within the named range depends on the total body weight, type of bacteria and severity of infectious process. Though the dosage for children is calculated based on weight, it is not recommended to use the medicine in children whose weight is less than 40 kilograms.
Even though the dosages for adults are the same for the treatment of all diseases for which Rulide is used, the lengths of the treatment courses are different:
- The treatment course of chronic osteomyelitis may last from 2 to 2,5 months
- The treatment course of pneumonia caused by Legionella can last up to 21 day
- The course of treatment of Chlamydia and Mycoplasma-induced pneumonia can last up to 15 days
- For airway infections the course can vary from 5 to 12 days of treatment.
For the treatment of children regardless of the infection or disease, the maximum treatment course should not exceed 10 days.
A doctor may change the length of the treatment course or prescribe a use of other antibiotics in combination with Rulide, so these numbers are for information only.
Rulide is contraindicated to be taken in patients with intolerance of other medicines with the same main active ingredient and erythromycin. The antibiotic contraindicated to pregnant or breastfeeding women and children under two months of age or with the body weight under 40 kilograms. Rulide must be carefully used in liver failure.
Unlike erythromycin, Rulide shows better compatibility with other medicines. Nevertheless, in order to avoid severe adverse reactions it is contraindicated to be used with Ergotamine, Dihydroergotamine, and Warfarin or identical medicines marketed under different names.
Side effects of Rulide
As any other antibiotics, Rulide is able to cause a wide range of adverse reactions. Majority of them are manifested slightly. Severe side effects can be caused by hidden health problems or hypersensitivity to the medicine’s components. Usual side effects that occur in the use of any antibiotic include: flatulence, diarrhea, decreased appetite, heartburn, vomiting, jaundice, nausea, flatulence, diarrhea, pancreatitis, pseudomembranous enterocolitis. In overdose or problems with liver, hepatocellular or cholestatic acute hepatitis may develop. There can occur also the side effects influencing nervous system: sleepiness, fatigue, dizziness, headache, fever, and bronchial spasm. Allergic manifestations include appearance of rash, itching, anaphylaxis, and alteration in senses of smell and taste. The use of the medicine without proper fungal prevention may result in the development of oral or vaginal candidiasis.
Buy Rulide online without a prescription at prices several times cheaper than your local drugstores offer. Find out more reading the article.
Some wide-spread and easy-to-catch diseases as even a common cold may result in unpleasant complications. In improper or untimely treatment of flu or cold even a healthy organism may be subjected to an infection attack on its upper and lower airways or even urinary tract. Such complications are treated with antibiotics. When the virus didn’t get killed, bacteria take its place and start to interfere with the normal function of various organs. Normally, if you had running nose or sore throat you can develop pharyngitis, laryngitis, and sinusitis. If during a common cold or flu you cough a lot but do not expectorate, you are in danger of bronchitis development. However, it is not so scary. Correctly chosen antibiotic drug, right dosage, and treatment course length can do wonders. Today we are even more fortunate as we can buy Generic Rulide online without a prescription. Worth noting, however, that antibiotics can harm your immune system or result in candidiasis development if taken improperly. The best way to figure out the optimal treatment plan is to consult a doctor.
What do doctors prescribe in such cases?
One of the most commonly prescribed antibiotics for the diseases described above is Generic Rulide. It is a derivative from erythromycin with wider spectrum and more pronounced efficacy against Gram-negative bacteria. The medicine is considered relatively safe and can be given even to children starting from two months of age in case their weight is over 40 kilograms.
Generic Rulide is also prescribed in bone diseases such as periostitis and chronic osteomyelitis. It is widely used to treat urinary tract diseases and sexually transmitted infections. Rulide is prescribed by dentists to prevent bacteremia and treat periodontitis.
How to buy Generic Rulide?
You can buy Generic Rulide online without a prescription if you need a repeated treatment and do not want to go to your doctor or if your doctor recommended you to take the medicine for 21 day and you do not want to spend a fortune buying it at your local drugstores. Online purchase is an amazing way to save, but be sure to observe your doctor’s recommendations and do not try to save on shipment – timely treatment with fast delivery can be more effective than postponed one.
Recommended dosages of Generic Rulide
If you buy Generic Rulide online without prescription, you still need to follow the recommendations of your doctor or at least generally approved rules:
Adults should take 2 pills of Generic Rulide 150 mg a day – one pill before breakfast and second – before dinner on an empty stomach. If you have any serious liver problem, the dosage should be cut in two.
Children are prescribed to use suspension. The dosage is calculated as follows: 5-8 milligrams per kilogram of the body weight. It is quite tricky to calculate the right dosage considering that in some cases 5 milligrams will be enough but some infectious processes need a higher dosage. For a safe use, it is a must to consult a pediatrician.
The length of the treatment course depends on the condition treated. For children, the course should not exceed 10 days in any case. In various types of pneumonia the treatment course length can vary from 14 to 21 days. The treatment of osteomyelitis can take up to 2,5 months.
Possible side effects of Generic Rulide
The most dangerous side effects of Generic Rulide may manifest in individual hypersensitivity to the medicine. In liver failure the medicine should be also taken cautiously. General side effects include digestion problems, diarrhea, dizziness, headache, rash, itching, pancreatitis, nausea, flatulence, and so on.