Medical description: Suprax is an antibiotic based on an active substance Cefixime used to treat various respiratory tract and genitourinary infections. The medicine is active among vast variety of gram-negative and some gram-positive bacteria. In order to be sure that the medicine is effective in certain patient, susceptibility tests are advised.
The medicine is contraindicated in hypersensitivity to the cephalosporin class of antibiotics, breastfeeding women, and children under aged less than six months.
Suprax is supplied 200mg and 400mg capsules and granules for suspension preparation.
Synonyms: Cefixx, Lupicef, Sefi, Sifi, Cefixoral, Cefspan, Cephoral, Oroken, Unixime
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Suprax or Cefixime is an antibiotic medicine used to treat various bacterial infections. The medicine is a modification of cephalosporin listed in the World Health Organization's List of Essential Medicines.
The medicine is classified as third generation cephalosporin. The “generations” of the Suprax active substance are modifications of the initial structure aimed to make the medicine fight wider range of bacteria. Clinical trials show that each new generation of the active substance is more effective against Gram-negative bacteria but at the same time is less effective against Gram-positive organisms.
The medicine is sold in all countries of the world, however, it can be found under different trade names registered by different pharmaceutical companies. For example, it can be found under the names Ofex, Trixon-O, Caricef, Cexim, and others.
S up rax mechanism of action
Suprax and other medicines with the same composition inhibit the synthesis of the pathogen cell membrane. The medicine attaches to one of the penicillin binding proteins responsible for the prevention of the transpeptidation step of the peptidoglycan synthesis in the walls of bacteria cell. Ruining the cell walls of bacteria through inhibition of biosynthesis, Suprax causes pathogen cell death.
Chemical properties of Suprax
The chemical formula of the active substance of Suprax is C16H15N5O7S2.3H2O. Additional ingredients in oral suspension form of the medicine are: strawberry Guarana flavor, sucrose, colloidal silicon dioxide, and xanthan gum.
Inside the Suprax capsule a mixture of powder made of small granules of yellow-white color is contained. The powder for oral suspension preparation consists of small granules of white or cream color. In preparation of suspension, when adding the water to the powder, a white-creamy substance is achieved with a sweet aroma of strawberry.
Pharmacokinetics of Suprax
In the oral intake, the bioavailability (the quantity of the active substance achieving the infection centre) of the active substance is 40-50% regardless of the time of intake (before or after meal). However, the maximum bioavailability is a bit lowered in plasma when the medicine is taken with meal.
The maximum concentration of the medicine in plasma in intake of Suprax 200mg capsules is achieved in 4 hours and is 2 microgram per milliliter of plasma. In the intake of 400 mg capsules, the concentration achieved is 3,5 microgram per milliliter of plasma. In the use of Suprax suspension, in intake of 200 mg, the maximum concentration is achieved in 4 hours and is 2.8 microgram per milliliter of plasma, in intake of 400 mg of suspension – 4.4 microgram per milliliter of plasma. The binding to plasma proteins, mainly albumin, is 65%.
High concentration of the medicine is found in urine and bile. The maximum amount of the medicine is excreted in urine – 50% during the 24 hours after the intake. About 10% is excreted in bile.
When Suprax is prescribed
Before using Suprax or other medicine with the same effect, it is advisable to perform cultures and susceptibility tests to identify the pathogen type and its sensitivity to cefixime (main active substance).
Suprax is effective in the treatment of diseases caused by Streptococcus agalactiae; Haemophilus parainfluenzae, Proteus vulgaris, Pasteurella multocida, Salmonella spp., Klebsiella pneumoniae, Klebsiella oxytoca, Providencia spp., Shigella spp., Citrobacter amalonaticus, Citrobacter diversus, Serratia marcescens, Streptococcus pneumoniaе, Haemophilus influenzae, Moraxella (Branhamella) catarrhalis, E.coli, Proteus mirabilis, Neisseria gonorrhoeae, Streptococcus pyogenes. It is not effective for the elimination of infection caused by Pseudomonas spp., Enterococcus (Streptococcus) of D serogroup, Listeria monocytogenes, majority of Staphylococcus spp. (including methicillin-resistant strains), Enterobacter spp., Clostridium spp., and Bacteroides fragilis.
The medicine is prescribed to treat: pharyngitis, tonsillitis, sinusitis; acute and chronic bronchitis; otitis media; uncomplicated urinary tract infections; uncomplicated gonorrhea.
The release form of Suprax
Suprax is released in form of granules of 30 grams for 60 milliliters of suspension (or other in different manufacturer), and capsules of 200 mg and 400 mg.
Dosages of Suprax
Adults and children over 12 years of age are prescribed to take Suprax in capsules. For adults and children aged over 12 years and body mass over 50 kilograms, the daily dose is 400 mg in a single intake or 200 mg taken two times a day. The average treatment course length is 7-10 days. The treatment course of infections caused by Streptococcus pyogenes is 10 days.
In uncomplicated gonorrhea the dosage is 400 mg once a day.
Children under 12 years of age are prescribed to take the suspension in dosage of 8 milligrams per kilogram of body weight in a single intake or in two intakes (4 mg per kilogram of body weight every 12 hours). For children aged from 6 months to 1 year, the daily dosage of suspension is 2.5 ml-4 ml, 2-4 years old – 5 ml, 5-11 years – 6ml-10 ml.
Contraindications and combination with other medicines
Suprax is contraindicated in patients with the allergy to all antibiotics from the cephalosporin class. The medicine is prohibited in breastfeeding. During the pregnancy, the medicine is advised only if the expected benefit to the mother outweighs the potential risk to the fetus. The medicine is strongly unadvised to be taken in children aged less than 6 months as the clinical trials have not yet confirmed the safety and effectiveness in this group of patients.
Adverse reactions of Suprax
Suprax may cause mostly mild side effects, such as flatulence, diarrhea, heartburn; nausea; stomach cramps or upset stomach. However, more severe side effects may occur: intense allergic reactions, blood in stool, fever, bruising or bleeding, genital itching or discharge, etc. If any of them occur, you should immediately seek medical attention.
Buy Suprax cheap at an online drugstore. Find out about the effective antibiotic and the ways to use it and buy safely online.
Suprax or Generic Suprax is one of the widely used antibiotics nowadays. It is prescribed by doctors to treat the complications of common cold or flu such as sinusitis, pharyngitis, tonsillitis, bronchitis, and otitis media. The medicine is also effective in the treatment of uncomplicated urinary tract infections, including uncomplicated gonorrhea.
Before prescribing Generic Suprax, doctors usually appoint certain tests to be sure that the diseases are caused by a pathogen sensible to the active substance of the medicine, cefixime. It is highly advisable to perform such susceptibility studies because the medicine is ineffective in certain infections caused by Enterococcus (Streptococcus) of D serogroup, Clostridium spp., Pseudomonas spp., Listeria monocytogenes, majority of Staphylococcus spp. (including methicillin-resistant strains), Enterobacter spp., and Bacteroides fragilis.
Worth noting, that the above mentioned tests and the medicine are quite expensive. If you need a prolonged treatment course, it would be wise to look for the cheaper analogs or at least cheaper sources from where to buy Generic Suprax at a lower price than your regular drugstores offer. The simplest and safest way to do so is to buy Generic Suprax online.
Online you can find not only Generic Suprax but a whole range of identical medicines marketed under different brand names, which are not less effective.
How to save on buying Generic Suprax online?
When you are prescribed to use the medicine, normally you need to start the treatment course as soon as possible to get the best and fastest results. In this case you should look for online pharmacies that offer fast shipment of Generic Suprax without charging too much for its delivery. Be sure also to check the reputation of the online pharmacy you choose via reviews left by customers and comparing the prices of the same medicines in several online drugstores. Do not choose the seller who offers suspiciously lower price. You can ask the seller if they sell Generic Suprax or the medicine cheaper analog. If the answer is Generic Generic Suprax, then lower price is justified. But if brand Generic Suprax is cheaper than at other online pharmacies, it can be of lower quality or with approaching expiration date. However, if you need the medicine for a 7-days-course, you can still opt for the medicine with an expiration date within the next few months if it significantly reduces its price and the seller is honest about it.
Another advantage of Generic Suprax online buy is that you can order the medicine even without a prescription. Of course, it is always wiser to use only the medicines prescribed by your doctor and avoid self-diagnoses. But if your doctor only recommended you to use the medicine without giving you a written rx, then Generic Suprax online buy is the best option for an effective treatment.
Precautions when using Generic Suprax
Every medicine and especially antibiotic has a list of contraindications and list of side effects. Before Generic Suprax online buy, make sure to read the instructions carefully and inform your doctor about all the conditions and allergies you have and medicines you take or plan to take. In occurrence of any slight side effects of Generic Suprax, consult your doctor about how can you adjust the medicine use or even replace it. If you experience severe side effects such as allergic reactions including trouble breathing, swollen throat, chest pains, severe stomach cramps – immediately call the ambulance.
Ordering Generic Suprax online cheaper you significantly save on your treatment, but do not save on measures to fight its side effects if they occur.