Medical description: Vantin is an antibiotic based on the active substance Cefpodoxime, a derivative from a fungus called Cephalosporium which antibacterial properties were discovered in 1945. The medicine is used for the treatment of respiratory and urinary tracts infections, skin and soft tissues infections and so on.
The recommended dosage of Vantin for adults is either 200 mg or 400 mg tablets or capsules a day divided in two intakes with equal intervals during the treatment course. For patients with liver or kidney impairment a reduced dosage is chosen.
Synonyms: Ceporex, Proxtl, Ancef, Biofuroksym, Ceclor, Cedax, Cefditoren, Cefizox, Cefotan, Ceftin, Cefurax, Cefuril, Cefuroxim, Cefzil, Duricef, Elobact, Fortaz, Keflex, Kefurox, Kefzol, Mandol, Maxipime, Mefoxin, Oraxim, Rocephin, Sharox, Tazicef, Velosef, Zinacef, Zinat
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Vantin is a brand name for a third-generation cephalosporin antibiotic (Beta-lactam antibiotics) based on an active substance called Cefpodoxime. The first antibiotic from the first generation was based on the fungus called Acremonium or Cephalosporium. It was discovered in 1945 and first sold for treatment purposes in 1964. With multiple research and alterations of the initial formula, the third generation of the most effective antibiotics from the class, in which Vantin is included, was derived. Studies show that with every new generation developed, the antibiotics provide more effect against Gram-negative bacteria which is often accompanied with the decreased efficacy against Gram-positive organisms.
The medicine is widely used to treat a variety of bacteria-induced illnesses of different systems and organs of the body. It can be found in any country, often, under different brand names. In the United Kingdome it can be bought as Cefpodoxime or Cefpodoxime Proxetil. In India, the medicine is called Akpod, Arodox, Atack, Baroxime, and so on. There are a thousand names for equivalents of Vantin. If you want to buy its cheaper analog online, you can simply look for Generic Vantin.
Vantin - Mechanism of action
Vantin prevents bacterial cell synthesis not allowing final transpeptidation stage of peptidoglycan synthesis happen in them. Already existing cell walls of the bacteria break while new cannot be formed leading to the pathogens death.
When Vantin is prescribed
Vantin and its other equivalents marketed under different names are used to treat mild and moderate infectious processes caused by majority of Gram-negative and Gram-negative bacteria with an exception of Bacteroides fragilis, Enterococcus, and Pseudomonas aeruginosa, which show a high level of resistance to the main ingredient of the drug. The medicine is commonly prescribed in upper and lower airways bacterial diseases such as tonsillitis, sinusitis, pharyngitis, tonsillitis, bronchitis, and pneumonia. It is also effective in uncomplicated urethral and cervical gonorrhea, rectal infections, infections of the skin and soft tissues, and urinary tract infections (cystitis).
The medicine can be prescribed for its off-label use if the doctor considers based on susceptibility tests that the bacteria causing the disease can be effectively eliminated with Vantin.
Pharmacokinetics of Vantin
When taken orally on an empty stomach, the amount of the active substance reaching the infection site is 40-50%. The medicine should not be taken with a meal. It can affect the absorbed amount and the overall efficiency. In patients suffering from cirrhosis of the liver, the absorption of the main substance of Vantin is lowered.
The peak concentration of Vantin in the blood plasma in oral intake of Vantin 200mg capsules is reached in four hours and amounts to two micrograms per milliliter of plasma. The concentration of 3,5 micrograms per milliliter of plasma is reached in the intake of Vantin 400mg capsule.
When suspension made of Vantin powder is used, the peak concentration is reached in 4 hours and is 2.8 microgram per milliliter of the plasma in use of 200 mg of correctly made suspension, in intake of 400 mg of suspension – 4.4 microgram per milliliter of plasma concentration is achieved.
The highest concentration of Vantin or its analogs is found in urine and bile. With urine is exerted the most amount of the consumed medicine – around 50%. Only about 10% is exerted in bile and 5% in feces.
The release form of Vantin
The medicine can be found either in tablets or capsules of 200mg and 400mg. The powder for suspension preparation is supplied in different volume bottles depending on the manufacturer.
Prescribed dosages of Vantin
For adults, Vantin is prescribed to be taken orally regardless of the supply form by from 200 mg to 400 mg taken in two intakes. The break between intakes should be 12 hours. If the interval is too small, Vantin can harm the liver or kidneys as an overdose may take place. If taken more than 12 hours after the first intake of the day, the concentration of the drug is too small and can provide a lesser effect.
In impairment of the liver or kidneys, the daily dose should be decreased two times. Moreover, according to other conditions that the patient is suffering from or depending on the body mass, a doctor may decide on a different daily dosage and treatment course length.
Contraindications for Vantin use
Primarily, Vantin is contraindicated to people allergic to one of its components or any other cephalosporin antibiotic. It should be also carefully taken during pregnancy, by nourishing mothers, in people with liver or kidney problems, and in stomach ulcer.
Before starting using Vantin, you should inform your doctor on any conditions you have including chronic or acute diseases.
Adverse effects of Vantin
The medicine can cause a wide range of adverse effects starting from the inconspicuous itching or rash and discomforting such as diarrhea, nausea, vomiting, fatigue, headache, and indigestion to serious ones such as trouble breathing or heart rate instability, and so on. In mild side effects, it is advised to get in contact with your doctor for a recommendation on how to decrease them.
Vantin may cause also life threatening allergic reactions that require immediate medical assistance. In case of serious discomfort or pronounced symptoms of allergy, such as swollen tongue, a patient should immediately call the ambulance.
Interaction of Vantin with other medicines
Drug interactions can be dangerous if the medicines are incompatible. Inform your doctor on all the medicines you use on a permanent basis and those you plan to start using during the treatment with Vantin. If you decide on using any medicine after the consultation with your doctor, meet him or her again to discuss any newly added medicines to any of your treatments.
In general, Vantin negatively interacts with gentamicin, diuretics, antacids, live bacterial vaccines and cyclosporine. Sometimes the antibiotics may also reduce the effectiveness of birth control pills, patches, etc.
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Antibiotic drug Vantin is included in the third-generation of cephalosporins. It is a broad-spectrum antibiotic medicine effective against almost all Gram-negative and Gram-positive pathogens. The first generation of cephalosporins was based on the natural product, fungus Cephalosporium which antibacterial properties were first found in 1945. The medicine was used for the first time in 1964. Since then, multiple alterations of the formula were made resulting in the creation of more powerful and broader-spectrum antibiotic currently known in the USA as Vantin. In other countries, the same medicine is sold under different brand names. When looking for the medicine online, you can see it under such names as Apodoxin, Dxproxil, Finecef-AM, Ipod, Kudox, Baxemin, Cefodox, Cefpodoxim AL, and hundreds of others.
When is the medicine prescribed?
In order to avoid the development of bacteria, which caused the diseases, resistance to the treatment, it is advised to use the medicine only if it is proven that the pathogen caused the diseases is sensible to it. Vantin is generally prescribed for the treatment of higher and lower respiratory tract infections, including various nasal or throat infections, pneumonia, bronchitis, bladder infections, kidney infections, skin and soft tissue infections, and others.
How to use Vantin – recommended dosages
Recommended dosage of Vantin for adults is 200mg-400 mg divided in two intakes during the day (either by 100mg or by 200mg two times a day) with an interval of 12 hours. The medicine is advised to be taken on an empty stomach as this way its bioavailability is much higher that if taken after meal. However, in stomach problems it can be taken with meals.
The 12-hour-interval between the intakes ensures the optimal concentration of the active substance in the body for the whole day. Smaller intervals may result in liver or kidney problems while bigger ones in ineffectiveness of the medicine.
For patients with liver and kidney impairment or in other chronic conditions, the dosage of Vantin or its analogs is adjusted individually.
When is Vantin contraindicated?
Vantin is contraindicated to people with allergic reactions to all cephalosporins. It is not advised to pregnant or breastfeeding women and can be taken by them only if the anticipated positive effect of the medicine can overlap the negative effect to the baby.
What adverse effects can be expected from Vantin?
As any other medicine, Vantin may or may not cause side effects. The most common ones are itching, rash, indigestion, diarrhea, flatulence, and others.
In pronounced side effects such as swollen tongue, heart arrhythmia or trouble breathing, use of the medicine should be stopped immediately and medical assistance obtained.
How and where to buy Vantin?
If you have a prescription from your doctor, you can easily buy Vantin at your local drugstores. If you don’t have a prescription, you can opt for online Vantin buy. You can buy the medicine online even if you have a prescription but want to save on the treatment while using the recommended medicine. Online you can buy Vantin several times cheaper than at your local drugstores. However, make sure to check the composition of the medicine and quantity of active substance per pill in order to avoid overdosing.
If you want to buy cheap Vantin, look for the medicine manufactured in India or Eastern Europe. If you don’t know the names, simply look for Generic Vantin and you will get hundreds of results provided by your search engine.
When buying the medicine online, save wisely – observe the dosage and length of treatment course not to harm your health.