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Full Information about Antibiotic Generic Zithromax
Medical description: Zithromax is an antibiotic drug effective against both Gram-positive, Gram-negative. It is also used for the elimination of atypical bacteria. The medicine affects both intracellular and extracellular pathogens equally effectively.
The medicine is used for the treatment of skin infections, urinary and respiratory tract infections, including complications of flu or common cold.
Zithromax does not lose its efficacy in contact with gastric acid, so it can be taken without acid protectors.
The daily dosage for adults is 0.5g in the first day of treatment and 0.25g for subsequent 4 days.
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Zithromax or Azithromycin is a semi-synthetic antibiotic, the first one from a subclass of azalides different in structure from classical macrolides due to the fact that they have nitrogen in the macrolide ring making their molecule more stable.
The antibiotic was discovered in 1980 by a team of Croatian researchers working for a pharmaceutical company called Pliva. The medicine was first marketed in Eastern Europe in 1988. In Western Europe and the United states, the medicine was first marketed in 1991 by a pharmaceutical company Pfizer who purchased a license for the production and selling of the drug in these two regions and registered it under Zithromax brand name. The medicine nowadays can be bought in any country of the world though it can be found under different brand names: Merckazitro in the Netherlands, Novatrex in Brazil, Z-Pak in Canada, Ultreon in Germany, Ribotrex in Italy, and so on.
Besides broad-spectrum activity of Zithromax meaning that the medicine is effective against the majority of known pathogens, the improvements made in its formula make it 300 times more acid-stable than Erythromycin. It means that the medicine is perfectly absorbed and does not lose its effectiveness in the contact with hydrochloric acid when reaching the stomach. Unlike other less acid-stable antibiotics, Zithromax can be used without protectors from acids.
Another advantage of Zithromax or rather its generics (cheaper, less advertised equivalents) is that is relatively cheap: the cost of a single dosage in the USA is from 18 cents to 3 dollars. Therefore, the treatment course cost may be reduced to 20-30 Dollars.
Zithromax - Mechanism of action
Zithromax blocks the growth of bacteria inhibiting the protein synthesis in their cells. It prevents the translocation of Messenger RNA through the binding with the ribosome of the bacteria.
When Zithromax is prescribed
Zithromax is a broad-spectrum antibiotic effective against Gram-positive, Gram-negative, and atypical bacteria. It acts both on extracellular and intracellular pathogens. Zithromax is prescribed for the treatment of diseases of the respiratory tract, such as bronchitis, sinusitis, tonsillitis, pharyngitis, pneumonia, and others. It is also effective in the treatment of otitis media, urethritis, gonococcal infection, skin infections, Lyme disease, toxoplasmosis, Chlamydia, botulism, and gas gangrene.
The diseases listed above in order to be treated properly with Zithromax should be caused by the bacteria it is effective against - Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus ducreyi, Moraxella catarrhalis, Neisseria gonorrhoeae, Bordetella pertussis, Legionella pneumophila, Haemophilus influenza, and some others. The medicine is ineffective against Gram-positive bacteria resistant to erythromycin. In order to be sure that the antibiotic fits the treatment, a doctor should appoint a susceptibility test.
Pharmacokinetics of Zithromax
Zithromax, as the majority of antibiotic medicines, is more effective when taken on an empty stomach. The maximum concentration of the medicine in the body is achieved from 2 to 3 hours after the oral intake. The medicine in great amounts is accumulated in phagocytes, which allows it quickly transport to the infection site. The half-life (time during which the medicine is fully eliminated from the body) of the medicine in a single dose is from 11 to 14 hours. In a single large dose of 500 mg, the half-life of Zithromax is 68 hours. It prolongs bacteriostatic effectiveness in infection sites for several days.
The medicine is excreted mostly in bile and only about 6% in urine.
Release form of Zithromax
Zithromax is supplied in pills, capsules, and suspension or granules for suspension preparation for oral use. It can be also administered to a patient by medical personnel as intravenous injection. In ophthalmology, the medicine is used in form of solution.
Prescribed dosages of Zithromax
The medicine should be taken one hour prior to meals or two hours after any food was eaten for better efficiency. When taken orally, Zithromax should be taken once a day. For the treatment of upper and lower airways infections, skin and soft tissue infections in adults the dosage is 0.5 grams in the first day with subsequent reduction to 0.25 grams from the second to fifth day of the treatment course.
Three-day-course is also possible. During it, the medicine is to be taken by 0.5 grams daily (maximum dosage per course is 1.5 grams).
In the acute infections of urogenital (genitourinary) tract, a single dose of 1 gram (2 tablets, capsules of 0.5 grams) is prescribed.
For the treatment of Lyme disease, for the first stage is prescribed a dosage of 1 gram in the first day and 0.5 grams in every following day during 4 days.
For children, the dosage of Zithromax is calculated based on the body weight. Children with the weight over 10 kilograms are prescribed to be administered 10 mcg per one kilogram of body weight in the first day and 5 micrograms per kilogram of body weight during the following 4 days of course. For a three-day treatment course, a single daily dose is 10 mcg per one kilogram of body weight. The maximum dosage for a three-day course is 30 micrograms per one kilogram of body weight.
Contraindications for Zithromax use
The medicine is contraindicated to people with hypersensitivity to the macrolide antibiotics. It should be taken carefully by people with kidney and liver problem. Pregnant and breastfeeding women are advised Zithromax only if the forecasted positive effects for their health are greater than harm to the fetus or baby.
Adverse effects of Zithromax
The use of Zithromax may cause nausea, diarrhea, abdominal pain, flatulence (gas accumulation in the intestines), and increase in the liver enzymes production. Rarely, vomiting or skin rash can be observed.
Interaction of Zithromax with other medicines
When used at the same time with the medicines lowering stomach acidity, it recommended taking the medicines with an interval of at least two hours.
Treat infections with Zithromax for only about 15 Dollars for a course of treatment. Find out about Zithromax online buy and dosages in the article.
Zithromax is a wide-spectrum antibiotic medicine used to treat a variety of infections. The medicine was discovered in 1980 and used in Eastern Europe in 1988. Nowadays, it is marketed all over the world under various brand names. For example, Zithromax is sold as 3-Micina in Ecuador, Agitro in Vietnam, Aziquilab in Peru, Hemomicin in Georgia, Azithrus in Russia, Azitops in South Korea, and so on. In total, there are over a few hundred registered names for the same medicine manufactured by different pharmaceutical companies.
The medicine is effective against almost all known Gram-negative and Gram-positive bacteria, some anaerobic bacteria, and atypical pathogens. Its additional advantage is that it is acid-resistant, meaning that its medical properties are not negatively affected by the gastric juice.
Though Zithromax is a prescription medicine, it, and especially its so-called generics (identical medicines with less advertised trade names) is quite inexpensive. A complete treatment course may cost you around 10-20 Dollars.
When is Zithromax prescribed?
Zithromax is used in the treatment of various diseases including frequent complications after a common cold or flu, such as bronchitis, pneumonia, sinusitis, otitis media, pharyngitis, tonsillitis, and others. It is also used in the treatment of uncomplicated skin and soft tissue infections, Urethritis and cervicitis caused by Chlamydia trachomatis or Neisseria gonorrhoeae. The medicine is prescribed also for such rare conditions in adults as babesiosis, bartonellosis, chancroid, Lyme disease, pertussis, toxoplasmosis, and others.
For children older than 6 months of age, the medicine is prescribed for the treatment of acute otitis media, acquired pneumonia, if induced by the bacteria susceptible to the drug.
Children of 2 and over years of age are prescribed Zithromax for the treatment of pharyngitis and tonsillitis induced by Streptococcus pyogenes when children are allergic to the primarily recommended medicines in these conditions.
Whom is Zithromax contraindicated?
The medicine should not be taken by patients with an allergy to the main component of the medicine, azithromycin dihydrate. It is also not recommended to the patients with severe pneumonia when oral intake of the antibiotic drugs is not justified as it may lead to serious complications. Pregnant or nourishing women are prescribed the medicine if the anticipated results of the treatment are greater than the harm to the baby. Patients with the liver or kidney function impairment are advised to take smaller dosages.
Dosages of Zithromax used in various diseases
It is advised to use the medicine one hour before meal or two hours after. Zithromax daily dosage is consumed in one intake.
Adults are prescribed 0.5 grams Zithromax in the first day of treatment and 0.25 grams for the following 4 days of treatment when used for respiratory tract infections and skin infections. If the treatment course is only three days, the daily dosage for each day is 0.5 grams.
For the treatment of acute urinary tract infections, the treatment consists of a single dosage of Zithromax 1 gram.
Lyme disease of the first stage requires the intake of 1 gram in the first day and 0.5 grams in every following day. The total length of the course is 5 days.
Children are prescribed Zithromax suspension which dosage is calculated based on body weight. Children over 10 kilograms are prescribed 10 mcg per one kilogram of body weight in the first day of the treatment and 5 micrograms per kilogram for the following 4 days.
When a three-day treatment plan is chosen, a single daily dose is 10 mcg per one kilogram of body weight. The total dosage of the active substance containing in the suspension should not exceed 30 mcg per one kilogram of body weight.